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Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bode, Ann M. | - |
dc.contributor.author | Ma, Wei-Ya | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.contributor.author | Dong, Zigang | - |
dc.date.accessioned | 2021-01-31T10:23:55Z | - |
dc.date.available | 2021-01-31T10:23:55Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2001-02 | - |
dc.identifier.citation | Cancer Research, Vol.61 No.3, pp.850-853 | - |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.other | 4909 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172895 | - |
dc.description.abstract | Many spices, including plants of the ginger family, possess anticarcinogenic activity. However, the molecular mechanisms by which they exert their antitumorigenic effects are unknown. Activator protein 1 (AP-1) has a critical role in tumor promotion, and blocking of tumor promoter-induced activation of AP-1 inhibits neoplastic transformation. Epidermal growth factor induces cell transformation and AP-1 activity. The purpose of this study was to investigate the effect of two structurally related compounds of the ginger family, [6]-gingerol and [6]-paradol, on EGF-induced cell transformation and AP-1 activation. Our results provide the first evidence that both block EGF-induced cell transformation but act by different mechanisms. | - |
dc.language | 영어 | - |
dc.publisher | American Association for Cancer Research | - |
dc.title | Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.citation.journaltitle | Cancer Research | - |
dc.identifier.wosid | 000167020100012 | - |
dc.identifier.scopusid | 2-s2.0-0035110888 | - |
dc.citation.endpage | 853 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 850 | - |
dc.citation.volume | 61 | - |
dc.identifier.sci | 000167020100012 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SKIN TUMOR PROMOTION | - |
dc.subject.keywordPlus | FACTOR RECEPTOR | - |
dc.subject.keywordPlus | AP-1 TRANSACTIVATION | - |
dc.subject.keywordPlus | HL-60 CELLS | - |
dc.subject.keywordPlus | MOUSE SKIN | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | MICE | - |
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