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Enzymatic reduction of xenobiotic α,β-unsaturated ketones: Formation of allyl alcohol metabolites from shogaol and dehydroparadol : Enzymatic reduction of xenobiotic alpha,beta-unsaturated ketones: Formation of allyl alcohol metabolites from shogaol and dehydroparadol
DC Field | Value | Language |
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dc.contributor.author | Surh, Y. J. | - |
dc.contributor.author | Lee, Sang Sup | - |
dc.date.accessioned | 2021-01-31T10:24:02Z | - |
dc.date.available | 2021-01-31T10:24:02Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 1994-04 | - |
dc.identifier.citation | Research Communications in Chemical Pathology and Pharmacology, Vol.84 No.1, pp.53-61 | - |
dc.identifier.issn | 0034-5164 | - |
dc.identifier.other | 5566 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172897 | - |
dc.description.abstract | A novel reductive metabolism of shogaol [1-(4'-hydroxy-3'-methoxyphenyl)-deca-4-ene-3-one], a major pungent and pharmacologically active principle of ginger, was investigated in rat liver in vitro. The ethyl acetate extractable metabolites formed by incubation of this alpha,beta-unsaturated ketone with rat liver 12,000 x g supernatant fortified with NADPH-generating system were analyzed by high performance chromatography and gas chromatography/mass spectrometry. In addition to the saturated ketone and reduced alcohol metabolites, an allyl alcohol, 1-(4'-hydroxy-3'-methoxyphenyl)-deca-4-ene-3-ol, was identified as a new metabolite of shogaol Likewise, dehydroparadol [1-(4'-hydroxy-3'-methoxyphenyl)-deca-1-ene-3-one], a non-pungent analog of shogaol, was also reduced to the corresponding allyl alcohol by the postmitochondrial fraction of rat kidney in the presence of NADPH-generating system. | - |
dc.language | 영어 | - |
dc.publisher | PJD Publications Ltd. | - |
dc.title | Enzymatic reduction of xenobiotic α,β-unsaturated ketones: Formation of allyl alcohol metabolites from shogaol and dehydroparadol | - |
dc.title.alternative | Enzymatic reduction of xenobiotic alpha,beta-unsaturated ketones: Formation of allyl alcohol metabolites from shogaol and dehydroparadol | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.citation.journaltitle | Research Communications in Chemical Pathology and Pharmacology | - |
dc.identifier.wosid | A1994NG97000006 | - |
dc.identifier.scopusid | 2-s2.0-0027950889 | - |
dc.citation.endpage | 61 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 53 | - |
dc.citation.volume | 84 | - |
dc.identifier.sci | A1994NG97000006 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Y. J. | - |
dc.contributor.affiliatedAuthor | Lee, Sang Sup | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | HALOPERIDOL | - |
dc.subject.keywordPlus | REDUCTASES | - |
dc.subject.keywordPlus | LIVER | - |
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