S-Space Graduate School of Convergence Science and Technology (융합과학기술대학원) Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과) Journal Papers (저널논문_분자의학 및 바이오제약학과)
Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng
- Keum, Young-Sam; Park, Kwang-Kyun; Lee, Jong-Min; Chun, Kyung-Soo; Park, Jeong Hill; Lee, Seung Ki; Kwon, Hoonjeong; Surh, Young-Joon
- Issue Date
- Cancer Letters, Vol.150 No.1, pp.41-48
- ginseng; antioxidant; anti-tumor promotion; mouse skin carcinogenesis; ornithine decarboxylase
- Heat treatment of Panax ginseng C.A. Meyer at a temperature higher than that applied to the conventional preparation of red ginseng yielded a mixture of saponins with potent antioxidative properties. Thus, the methanol extract of heat-processed neo-ginseng (designated as 'NGMe') attenuated lipid peroxidation in rat brain homogenates induced by ferric ion or ferric ion plus ascorbic acid. Furthermore, the extract protected against strand scission in empty set X174 supercoiled DNA induced by UV photolysis of H2O2, and was also capable of scavenging superoxide generated by xanthine-xanthine oxidase or by 12-O-tetradecanoylphorbol-13-acetate (TPA) in differentiated human promyelocytic leukemia (HL-60) cells. Topical application of NGMe onto shaven backs of female ICR mice 10 min prior to TPA, significantly ameliorated skin papillomagenesis initiated by 7,12-dimethylbenz[a]anthracene. Moreover, TPA-induced enhancement of epidermal ornithine decarboxylase (ODC) activity and ODC mRNA expression was abolished by a topical dose (0.68 mg) of NGMe. Likewise, TPA-induced production of tumor necrosis factor- in mouse skin was inhibited by NGMe pretreatment. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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