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Resolution of inflammation as a novel chemopreventive strategy

Cited 25 time in Web of Science Cited 26 time in Scopus
Authors
Lee, Ha-Na; Na, Hye-Kyung; Surh, Young-Joon
Issue Date
2013-03
Citation
Seminars in Immunopathology, Vol.35 No.2, pp.151-161
Keywords
CancerChemopreventionInflammation-associated carcinogenesisLipid mediatorsLipid mediator class switchingProstaglandinsResolution of inflammationResolvins
Abstract
Acute inflammation, a physiologic response to protect cells from microbial infection and other noxious stimuli, is automatically terminated by endogenous anti-inflammatory and pro-resolving mediators to restore homeostatic conditions. However, if timely resolution of inflammation is failed, inflammation persists and can progress to a chronic inflammation which has long been thought as a predisposing factor to carcinogenesis. Excessive and pathologic inflammation causes DNA damage, genomic instability, epigenetic dysregulation, and alteration of intracellular signaling, all of which are involved in neoplastic transformation. To prevent chronic inflammation and resulting inflammation-promoted cancer development, understanding the process that resolves inflammation is essential. Resolution of inflammation is an active coordinated process regulated by distinct anti-inflammatory and pro-resolving endogenous lipid mediators, such as resolvins and lipoxins. The role of pro-inflammatory signaling in carcinogenesis has become more and more evident and well characterized, but the potential role of pro-resolving mediators in cancer prevention remains still elusive. In searching for an efficacious way to prevent chronic inflammation-associated cancer, the pro-resolving signal transduction pathways and their regulators should be unraveled.
ISSN
1863-2297
URI
https://hdl.handle.net/10371/172904
DOI
https://doi.org/10.1007/s00281-013-0363-y
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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