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Cancer Chemopreventive and Therapeutic Potential of Guggulsterone

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Authors
Almazari, Inas; Surh, Young-Joon
Issue Date
2013
Citation
Topics in Current Chemistry, Vol.329, pp.35-60
Keywords
GuggulsteroneCancer chemopreventionGuggul plantsPhytochemicals
Abstract
Guggulsterone (GS) is a phytosterol derived from the gum resin of guggul plants that have been used traditionally to treat various disorders such as burns, wounds, gastric ulcer, cough, gum diseases, urinary complaints, diarrhea, stomach cramps, fascioliasis, and intestinal worms. It has anti-inflammatory and antioxidative properties and has recently attracted substantial attention due to its cancer chemopreventive and therapeutic potential exemplified by its antiproliferative, antimetastatic, and proapoptotic properties in many cancer cell lines and animal models. This review highlights some of the cancer chemopreventive/therapeutic targets of GS and the underlying molecular mechanisms.
ISSN
0340-1022
URI
https://hdl.handle.net/10371/172906
DOI
https://doi.org/10.1007/128_2012_344
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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