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Induction of apoptosis in HL-60 cells by pungent vanilloids, [6]-gingerol and [6]-paradol
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Eunyong | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T10:25:09Z | - |
dc.date.available | 2021-01-31T10:25:09Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 1998-12 | - |
dc.identifier.citation | Cancer Letters, Vol.134 No.2, pp.163-168 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.other | 5203 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172914 | - |
dc.description.abstract | [6]-Gingerol, a major pungent ingredient found in the rhizome of ginger, has been reported to possess a strong antiinflammatory activity, which is considered to be closely associated with its cancer chemopreventive potential. [6]-Paradol, another pungent phenolic substance found in ginger and other Zingiberaceae plants, also has a vanilloid structure found in other chemopreventive phytochemicals including curcumin. In the present study, [6]-gingerol and [6]-paradol were found to exert inhibitory effects on the viability and DNA synthesis of human promyelocytic leukemia (HL-60) cells. The cytotoxic and antiproliferative effects of both compounds were associated with apoptotic cell death. The above results suggest that [6]-gingerol and [6]-paradol possess potential cytotoxic/cytostatic activities. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Induction of apoptosis in HL-60 cells by pungent vanilloids, [6]-gingerol and [6]-paradol | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1016/S0304-3835(98)00253-5 | - |
dc.citation.journaltitle | Cancer Letters | - |
dc.identifier.wosid | 000077949600006 | - |
dc.identifier.scopusid | 2-s2.0-0032431687 | - |
dc.citation.endpage | 168 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 163 | - |
dc.citation.volume | 134 | - |
dc.identifier.sci | 000077949600006 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | DIETARY CURCUMIN | - |
dc.subject.keywordPlus | TUMOR PROMOTION | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | CHEMOPREVENTION | - |
dc.subject.keywordPlus | CARCINOGENESIS | - |
dc.subject.keywordPlus | PROSTAGLANDIN | - |
dc.subject.keywordPlus | BIOSYNTHESIS | - |
dc.subject.keywordPlus | TARGET | - |
dc.subject.keywordPlus | LINES | - |
dc.subject.keywordAuthor | [6]-gingerol | - |
dc.subject.keywordAuthor | [6]-paradol | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | HL-60 cells | - |
dc.subject.keywordAuthor | ginger | - |
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