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Suppression of mouse skin tumor promotion and induction of apoptosis in HL-60 cells by Alpinia oxyphylla Miquel (Zingiberaceae)

Cited 58 time in Web of Science Cited 70 time in Scopus
Authors
Lee, Eunyong; Park, Kwang-Kyun; Lee, Jong-Min; Chun, Kyung-Soo; Kang, Jee-Young; Lee, Sang-Sup; Surh, Young-Joon
Issue Date
1998-08
Citation
Carcinogenesis, Vol.19 No.8, pp.1377-1381
Abstract
There have been considerable efforts to search for naturally occurring substances for the intervention of carcinogenesis. Many components from dietary or medicinal plants have been identified that possess substantial chemopreventive properties. An example is curcumin (Curcuma longa Linn,, Zingiberaceae), which has been shown to inhibit tumor promotion in experimental carcinogenesis. Alpinia oxyphylla Miquel, another plant of the ginger family used in oriental herbal medicine, contains diarylheptanoids whose structures are analogous to that of curcumin, In the present study, we have tested A,oxyphylla for its ability to suppress tumor promotion. Thus, topical application of the methanolic extract of dried fruits of A,oxyphylla significantly ameliorated 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin tumor promotion as well as ear edema in female ICR mice. In another study, treatment of HL-60 cells with the methanolic extract of A. oxyphylla significantly reduced the viability of the cells and also inhibited DNA synthesis. Microscopic examination of the treated cells showed characteristic morphology of apoptosis, Furthermore, cells treated with the extract of A. oxyphylla exhibited internucleosomal DNA fragmentation in time- and concentration-dependent manners. TPA-stimulated generation of superoxide anion in differentiated HL-60 cells was also blunted by A. oxyphylla, Taken together, these findings suggest that A,oxyphylla possesses potential chemopreventive and antitumorigenic activities.
ISSN
0143-3334
URI
https://hdl.handle.net/10371/172915
DOI
https://doi.org/10.1093/carcin/19.8.1377
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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