염증 해소를 통한 발암 억제

Abstract

Uncontrolled and excessive inflammation results in chronic inflammation, which has long been thought to contribute to the development of cancer. Chronic inflammatory conditions predispose susceptible cells to malignant transformation. To prevent the inflammation-associated cancer, resolution of inflammation is essential. Resolution of inflammation is an active coordinated process regulated by a distinct set of anti-inflammatory and pro-resolving mediators, such as resolvins. However, the inflammation-cancer connection is not limited to an increased risk for tumorigenesis. Recently, it has also been suggested that oncogenic changes can induce inflammation that stimulates the development of tumors. In the tumor microenvironment, cancer-associated inflammation contributes to proliferation and survival of malignant cells, angiogenesis, metastasis, immunesuppression, and reduced response to chemotherapeutic agents. Paradoxically, there are parallels between the resolution of inflammation and the inflammatory microenvironment in cancer. Although resolution of inflammation prevents carcinogenesis, the precise roles of anti-inflammatory and pro-resolving signaling pathways in tumor progression are still unclear. To find novel preventive and therapeutic targets for management of cancer, the molecular pathways linking resolution of inflammation and cancer should be unraveled.