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Effects of capsaicin on chemically-induced two-stage mouse skin carcinogenesis

Cited 38 time in Web of Science Cited 41 time in Scopus
Authors
Park, Kwang-Kyun; Surh, Young-Joon
Issue Date
1997-03
Citation
Cancer Letters, Vol.114 No.1-2, pp.183-184
Keywords
capsaicintumor promotioncarcinogenesis
Abstract
Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is a principal pungent ingredient of hot red peppers. There are some controversies with regard to its inherent tumorigenicity and mutagenicity. The present work was undertaken to assess tumor initiating and promotional effects of capsaicin in a two-stage mouse skin carcinogenesis model. A single topical application of capsaicin (10 mu mol) followed by twice-weekly applications of 12-O-tetradecanoylphorbol-13-acetate onto shaven backs of female ICR mice resulted in no significant increases in incidence and multiplicity of skin tumors, compared with the solvent-pretreated control animals. Repeated topical applications of capsaicin alone failed to promote 7,12-dimethylbenz[a]anthracene-initiated mouse skin tumorigenesis, but moderately inhibited the papilloma formation when given prior to each topical dose of phorbol ester. (C) 1997 Elsevier Science Ireland Ltd.
ISSN
0304-3835
URI
https://hdl.handle.net/10371/172923
DOI
https://doi.org/10.1016/S0304-3835(97)04657-0
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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