S-Space Graduate School of Convergence Science and Technology (융합과학기술대학원) Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과) Journal Papers (저널논문_분자의학 및 바이오제약학과)
Chemopreventive effect of cholorophyllin on mutagenicity and cytotoxicity of 6-sulfooxymethylbenzo[a]pyrene
- Cho, Young-Sik; Kim, Bu-Yeo; Lee, Sung-Taek; Surh, Young-Joon; Chung, An-Sik
- Issue Date
- Cancer Letters, Vol.107 No.2, pp.223-228
- chlorophyllin; 6-sulfooxymethylbenzo[a]pyrene; antimutagenicity; Chinese hamster V79 cells; Salmonella typhimurium
- The chemopreventive activity of chlorophyllin (CHL) was monitored by using 6-sulfooxymethylbenzo[a]pyrene (SMBP) which is an ultimate metabolite of benzo[a]pyrene (B[a]P). CHL was quite effective in reducing both cytotoxicity and mutagenicity for SMBP in dose dependent manner up to 12.5 mM CHL in Chinese hamster V79 cells. The inhibitory patterns of CHL for SMBP were also confirmed in Salmonella typhimurium strains TA98 and TA100. Mutation frequency caused by SMBP was diminished almost to a control level at a 50 nmol CHL, A similar but less effective prevention of CHL was indicated in the mammalian and the bacterial mutagenicity assays with 6-hydroxymethylbenzo[a]pyrene (HMBP). The inhibitory effect of CHL against assault of SMBP on V79 cells was found to be related to the reduced cellular uptake of SMBP and further the remarkably lowered DNA adducts.
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