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Comparative effects of curcumin and tetrahydrocurcumin on dextran sulfate sodium-induced colitis and inflammatory signaling in mice

Cited 18 time in Web of Science Cited 0 time in Scopus
Authors
Yang, Joon-yeop; Zhong, Xiancai; Kim, Su-Jung; Kim, Do-Hee; Kim, Hyun Soo; Lee, Jeong-Sang; Yum, Hye-Won; Lee, Jee Woo; Na, Hye-Kyung; Surh, Young-Joon
Issue Date
2018-03
Citation
대한암예방학회지, Vol.23 No.1, pp.18-24
Keywords
CurcuminDextran sulfate sodium-induced colitisNF-kappa BSTAT3Tetrahydrocurcumin
Abstract
Background: Curcumin, a yellow ingredient of turmeric (Curcuma longa Linn, Zingiberaceae), has long been used in traditional folk medicine in the management of inflammatory disorders. Although curcumin has been reported to inhibit experimentally-induced colitis and carcinogenesis, the underlying molecular mechanisms remain largely unresolved. Methods: Murine colitis was induced by dextran sulfate sodium (DSS) which mimics inflammatory bowel disease. Curcumin or tetrahydrocurcumin was given orally (0.1 or 0.25 mmol/kg body weight daily) for 7 days before and together with DSS administration (3% in tap water). Collected colon tissue was used for histologic and biochemical analyses. Results: Administration of curcumin significantly attenuated the severity of DSS-induced colitis and the activation of NF-kB and STAT3 as well as expression of COX-2 and inducible nitric oxide synthase. In contrast to curcumin, its non-electrophilic analogue, tetrahydrocurcumin has much weaker inhibitory effects. Conclusions: Intragastric administration of curcumin inhibited the experimentally induced murine colitis, which was associated with inhibition of pro-inflammatory signaling mediated by NF-kB and STAT3. (J Cancer Prev 2018;23:18-24)
ISSN
2288-3649
URI
https://hdl.handle.net/10371/172933
DOI
https://doi.org/10.15430/JCP.2018.23.1.18
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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