S-Space College of Medicine/School of Medicine (의과대학/대학원) Internal Medicine (내과학전공) Journal Papers (저널논문_내과학전공)
Identification of genes differentially expressed between gastric cancers and normal gastric mucosa with cDNA microarrays
- Lee, Seongeun; Baek, Myungin; Yang, Hankwang; Bang, Yung-Jue; Kim, Woo Ho; Ha, Ji-Hong; Kim, Dae-Kee; Jeoung, Doo-Il
- Issue Date
- Cancer Letters, Vol.184 No.2, pp.197-206
- To identify genes whose alterations lead to gastric cancer, gene expression profiles have been obtained from 22 gastric cancer tissues and their surrounding gastric mucosa tissues. A total of 16 genes were differentially expressed in more than 50% of gastric cancer tissues compared with surrounding gastric mucosa tissues. Genes such as HMG-Y, fibroblast collagenase inhibitor, and osteopontin are among those that are overexpressed in over 50% of the gastric cancer tissues. Dihydrodiol dehydrogenase, ribonuclease A, and glutathione peroxidase are among those genes that are underexpressed in over 50% of the gastric cancer tissues. We identified genes that are associated with clinical phenotypes of patients with gastric cancers. Alpha-II spectrin, Na/K-ATPase and KIAA0111 are those that are enhanced in intestinal type of gastric cancer. Gene such as platelet-endothelial tetraspan antigen 3 was enhanced in highly metastatic gastric cancer tissues. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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