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Identification of genes differentially expressed between gastric cancers and normal gastric mucosa with cDNA microarrays

Cited 53 time in Web of Science Cited 58 time in Scopus
Authors
Lee, Seongeun; Baek, Myungin; Yang, Hankwang; Bang, Yung-Jue; Kim, Woo Ho; Ha, Ji-Hong; Kim, Dae-Kee; Jeoung, Doo-Il
Issue Date
2002-10
Citation
Cancer Letters, Vol.184 No.2, pp.197-206
Keywords
gastric cancercDNA microarraymetastasislauren
Abstract
To identify genes whose alterations lead to gastric cancer, gene expression profiles have been obtained from 22 gastric cancer tissues and their surrounding gastric mucosa tissues. A total of 16 genes were differentially expressed in more than 50% of gastric cancer tissues compared with surrounding gastric mucosa tissues. Genes such as HMG-Y, fibroblast collagenase inhibitor, and osteopontin are among those that are overexpressed in over 50% of the gastric cancer tissues. Dihydrodiol dehydrogenase, ribonuclease A, and glutathione peroxidase are among those genes that are underexpressed in over 50% of the gastric cancer tissues. We identified genes that are associated with clinical phenotypes of patients with gastric cancers. Alpha-II spectrin, Na/K-ATPase and KIAA0111 are those that are enhanced in intestinal type of gastric cancer. Gene such as platelet-endothelial tetraspan antigen 3 was enhanced in highly metastatic gastric cancer tissues. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
ISSN
0304-3835
URI
https://hdl.handle.net/10371/172942
DOI
https://doi.org/10.1016/S0304-3835(02)00197-0
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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