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MAPK signaling is involved in camptothecin-induced cell death
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Seongeun | - |
dc.contributor.author | Lee, Ho-Soon | - |
dc.contributor.author | Baek, Myunginq | - |
dc.contributor.author | Lee, Dae-Yeon | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.contributor.author | Cho, Hae-Nyun | - |
dc.contributor.author | Lee, Yun-Sil | - |
dc.contributor.author | Ha, Ji-Hong | - |
dc.contributor.author | Kim, Hae-Yeong | - |
dc.contributor.author | Jeong, Doo-Il | - |
dc.date.accessioned | 2021-01-31T10:59:38Z | - |
dc.date.available | 2021-01-31T10:59:38Z | - |
dc.date.created | 2020-12-21 | - |
dc.date.issued | 2002-12 | - |
dc.identifier.citation | Molecules and Cells, Vol.14 No.3, pp.348-354 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.other | 119320 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172947 | - |
dc.description.abstract | Camptothecin, a topoisomerase I inhibitor, is a well-known anticancer drug. However, its mechanism has not been well studied in human gastric cancer cell lines. Camptothecin induced apoptotic cell death in human gastric cancer cell line AGS. Z-VAD-fmk, pan-caspase inhibitor, blocked apoptotic phenotypes induced by camptothecin suggesting that caspases are involved in camptothecin-induced cell death. An inhibitor of caspase-6 or -8 or -9 did not prevent cell death by camptothecin. Various protease inhibitors failed to prevent camptothecin-induced cell death. These results suggest that only few caspases are involved in camptothecin-induced cell death. Camptothecin induced phosphorylation of ERK1/2, JNK, and p38 MAPK, in a dose and time-dependent manner in AGS. Z-VAD-fmk did not affect MAPK signaling induced by camptothecin suggesting that caspase signaling occurs downstream of MAPK signaling. Blocking of p38 MAPK, but not ERK1/2, resulted in partial inhibition of cell death and PARP cleavage by camptothecin in AGS. Taken together, MAPK signaling is associated with apoptotic cell death by camptothecin. | - |
dc.language | 영어 | - |
dc.publisher | 한국분자세포생물학회 | - |
dc.title | MAPK signaling is involved in camptothecin-induced cell death | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.citation.journaltitle | Molecules and Cells | - |
dc.identifier.wosid | 000180215300004 | - |
dc.identifier.scopusid | 2-s2.0-0037637701 | - |
dc.citation.endpage | 354 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 348 | - |
dc.citation.volume | 14 | - |
dc.identifier.sci | 000180215300004 | - |
dc.identifier.kciid | ART001006908 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | POLY(ADP-RIBOSE) POLYMERASE | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | CLEAVAGE | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordAuthor | AGS | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | camptothecin | - |
dc.subject.keywordAuthor | MAPK | - |
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