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Role of Adjuvant Chemoradiotherapy for Duodenal Cancer A Single Center Experience

Cited 15 time in Web of Science Cited 16 time in Scopus
Authors
Kim, Kyubo; Chie, Eui Kyu; Jang, Jin-Young; Kim, Sun Whe; Oh, Do-Youn; Im, Seock-Ah; Kim, Tae-You; Bang, Yung-Jue; Ha, Sung W.
Issue Date
2012-12
Citation
American Journal of Clinical Oncology, Vol.35 No.6, pp.533-536
Keywords
duodenal canceradjuvant treatmentchemoradiotherapy
Abstract
Objectives: To compare the treatment outcome of surgery alone with that of surgery followed by adjuvant chemoradiotherapy (CRT) for duodenal cancer. Methods: Between January 1991 and December 2002, 24 patients with duodenal cancer underwent pancreaticoduodenectomy. There were 14 males and 10 females, and median age was 61 years (range, 33-75). Nine patients received adjuvant CRT, and 15 did not. Postoperative radiotherapy was delivered up to 40 Gy at 2 Gy/fraction with a 2-week planned rest. Intravenous 5-fluorouracil (500 mg/m(2)/d) was given on days 1 to 3 of each split course. Median follow-up period was 32 months (range, 5-170). Results: Nodal stage and stage group were more advanced in CRT (+) group (P-0.0894 and 0.0361, respectively). However, other patient and tumor characteristics were similar in each group. Five-year overall survival rates of CRT (-) and CRT (+) group were 47% and 30%, respectively (P-0.3799). Five-year locoregional relapse-free survival rates of CRT (-) and CRT (+) group were 64% and 80%, respectively (P=0.4188). On multivariate analysis, patients treated with adjuvant CRT had better locoregional relapse-free survival with borderline significance (P=0.0750). No patient suffered grade 3 or higher toxicity during CRT. Conclusions: Adjuvant CRT is feasible and may enhance locoregional control in advanced-staged duodenal cancer after curative resection.
ISSN
0277-3732
URI
https://hdl.handle.net/10371/172949
DOI
https://doi.org/10.1097/COC.0b013e31821dee31
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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