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Antitumor activity of SK-7041, a novel histone deacetylase inhibitor, in human lung and breast cancer cells

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Authors
Lee, Keun-Wook; Kim, Jee Hyun; Park, Jung-Hyun; Kim, Hwang-Phill; Song, Sang-Hyun; Kim, Sang Gyun; Kim, Tai Young; Jong, Hyun-Soon; Jung, Kyung Hae; Im, Seock-Ah; Kim, Tae-You; Kim, Noe Kyeong; Bang, Yung-Jue
Issue Date
2006-09
Citation
Anticancer Research, Vol.26 No.5A, pp.3429-3438
Keywords
SK-7041histone deacetylase inhibitorlung cancerbreast cancerapoptosis
Abstract
Background: A class of synthetic histone deacetylase (HDAC) inhibitors, which are hybrids of trichostatin A and MS-275 were previously developed. In this study, the antitumor effects of SK-7041, one of those novel HDAC inhibitors, was evaluated on lung and breast cancer cell lines. Materials and Methods: Human lung and breast cancer cells, as well as normal human bronchial epithelial (NHBE) cells were treated with SK-7041, and results were compared with those of cells treated with suberoylanilide hydroxamic acid (SAHA). Results: SK-7041 induced time-dependent histone hyperacetylation and showed more potent cytotoxicity than SAHA in cancer cells. These antiproliferative effects of SK-7041 were due to apoptotic cell death caused by G21M-phase arrest and to a lesser extent to G1 arrest. Moreover, SK-7041 inhibited cancer cell proliferation more selectively than NHBE cell proliferation. Conclusion: These results suggest that SK-7041 may have potential anticancer activity.
ISSN
0250-7005
URI
https://hdl.handle.net/10371/172964
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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