S-Space College of Medicine/School of Medicine (의과대학/대학원) Internal Medicine (내과학전공) Journal Papers (저널논문_내과학전공)
Increased MAPK activity and MKP-1 overexpression in human gastric adenocarcinoma
- Bang, Yung-Jue; Kwon, Jin Hwa; Kang, Shin Hyeok; Kim, Jong Woo; Yang, Yun Chung
- Issue Date
- Biochemical and Biophysical Research Communications, Vol.250 No.1, pp.43-47
- Mitogen-activated protein kinase (MAPK) has been known to play a critical role in the regulation of the carcinogenesis in human cancers. In an effort to understand the functional role of the MAPK in the carcinogenesis of human gastric tissues, we examined the changes of MAPK levels in human gastric adenocarcinoma, We found that increased MAPK activity was accompanied by overexpression of mitogen-activated protein kinase phosphatase-l (MKP-1), suggesting that signaling pathways leading to the activation of MAPK and the induction of MKP-1 expression are associated with carcinogenesis of human gastric adenocarcinoma, (C) 1998 Academic Press.
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