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Increased MAPK activity and MKP-1 overexpression in human gastric adenocarcinoma

Cited 77 time in Web of Science Cited 84 time in Scopus
Authors
Bang, Yung-Jue; Kwon, Jin Hwa; Kang, Shin Hyeok; Kim, Jong Woo; Yang, Yun Chung
Issue Date
1998-09
Citation
Biochemical and Biophysical Research Communications, Vol.250 No.1, pp.43-47
Abstract
Mitogen-activated protein kinase (MAPK) has been known to play a critical role in the regulation of the carcinogenesis in human cancers. In an effort to understand the functional role of the MAPK in the carcinogenesis of human gastric tissues, we examined the changes of MAPK levels in human gastric adenocarcinoma, We found that increased MAPK activity was accompanied by overexpression of mitogen-activated protein kinase phosphatase-l (MKP-1), suggesting that signaling pathways leading to the activation of MAPK and the induction of MKP-1 expression are associated with carcinogenesis of human gastric adenocarcinoma, (C) 1998 Academic Press.
ISSN
0006-291X
URI
https://hdl.handle.net/10371/172980
DOI
https://doi.org/10.1006/bbrc.1998.9256
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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