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Sunitinib synergizes the antitumor effect of cisplatin via modulation of ERCC1 expression in models of gastric cancer

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Authors
Yoon, Young-Kwang; Im, Seock-Ah; Min, Ahrum; Kim, Hwang-Phill; Hur, Hyung-Seok; Lee, Kyung-Hun; Han, Sae-Won; Song, Sang-Hyun; Oh, Do Youn; Kim, Tae-You; Kim, Woo Ho; Bang, Yung-Jue
Issue Date
2012-08
Citation
Cancer Letters, Vol.321 No.2, pp.128-136
Keywords
SunitinibPDGFRA overexpressionChemosensitizer
Abstract
We evaluated the effects of sunitinib monotherapy and in combination with cisplatin in human gastric cancer cell lines. Sunitinib showed antiproliferative effect in gastric cancer cells line with high PDGFRA expression. Knockdown of PDGFRA showed that sunitinib sensitivity was correlated with the basal expression of PDGFRA. Synergistic growth inhibitory activity in combination with cisplatin was identified. We further explored how sunitinib potentiated the activity of cisplatin. We found that sunitinib treatment resulted in the down-regulation of ERCC1 expression via the modulation of PDGFRA expression in gastric cancer cells. The effect was verified via SNU484 xenograft model. Our data support the rationale of clinical trial using sunitinib in combination of cisplatin in gastric cancer. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
ISSN
0304-3835
URI
https://hdl.handle.net/10371/172981
DOI
https://doi.org/10.1016/j.canlet.2012.01.019
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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