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Efficacy of modified regimen with attenuated doses of paclitaxel plus carboplatin combination chemotherapy in elderly and/or weak patients with advanced non-small cell lung cancer

Cited 23 time in Web of Science Cited 24 time in Scopus
Authors
Choi, In Sil; Kim, Byung Su; Park, Sook Ryun; Lee, Sang Yoon; Kim, Do Yeun; Kim, Jee Hyun; Lee, Se Hoon; Kim, Tae-You; Heo, Dae Seog; Bang, Yung-Jue; Kim, Noe Kyeong
Issue Date
2003-01
Citation
Lung Cancer, Vol.39 No.1, pp.99-101
Keywords
carboplatinchemotherapynon-small cell lung cancerpaclitaxel
Abstract
Purpose: We conducted this studs to evaluate the activity and toxicity of a combination regimen of paclitaxel plus carboplatin in patients with advanced NSCLC aged 65 years or older and/or in those with an ECOG performance status (PS) 2. Materials and methods: Chemotherapy-naive patients with unresectable pathologically-proven NSCLC and of either age greater than or equal to 65 or ECOG PS 2 were eligible. Patients received modified regimen with attenuated doses of paclitaxel (135 mg/m(2) i.v. for 3 h D1) and carboplatin (AUC = 5, D1) every 3 weeks. Results: Thirty-five patients were enrolled. Nineteen patients were aged 65 or older (54%) and 26 patients (74%) were ECOG PS 2. The objective response rate was 40% with 14 partial responses. The median time to progression was 22 weeks. Grade 3 leucopenia occurred in 1 cycle and one case of neutropenic fever. Conclusions: The modified regimen with attenuated doses of paclitaxel plus carboplatin combination chemotherapy was effective and well tolerated in patients with advanced NSCLC aged 65 years or older and for in those with ECOG PS 2. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
ISSN
0169-5002
URI
https://hdl.handle.net/10371/172992
DOI
https://doi.org/10.1016/S0169-5002(02)00389-6
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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