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MET in gastric carcinomas: comparison between protein expression and gene copy number and impact on clinical outcome

Cited 129 time in Web of Science Cited 133 time in Scopus
Authors
Lee, H. E.; Kim, M. A.; Lee, H. S.; Jung, E-J; Yang, H-K; Lee, B. L.; Bang, Yung-Jue; Kim, W. H.
Issue Date
2012-07
Citation
British Journal of Cancer, Vol.107 No.2, pp.325-333
Keywords
stomach neoplasmMETimmunohistochemistrysilver in-situ hybridisationgene amplification
Abstract
BACKGROUND: The aim of this study was to compare gene copy number (GCN) and protein expression of MET and to evaluate their prognostic roles in gastric carcinomas. METHODS: MET protein expression and gene amplification (GA) status were determined by immunohistochemistry (IHC) and silver in-situ hybridisation (SISH), respectively, in a large series of gastric carcinoma. RESULTS: Protein overexpression was observed in 104 of 438 cases, with IHC 2+ in 94 and IHC 3+ in 10, and high polysomy of chromosome 7 and GA were found in 61 and 13 of 381, respectively. Direct comparison revealed a significant correlation between high level of protein expression and increased GCN. All cases with GA showed protein overexpression. Furthermore, all with IHC 3+ showed GA except 1, even which could be categorised as GA according to the ASCO/CAP guideline for human epidermal growth factor receptor 2 assessment. IHC 3+ and GA were significantly associated with poor prognosis. CONCLUSION: MET IHC reflects well on GA, and therefore, it could be a primary screening test for patient selection for anti-MET therapy if GA is a major determinant of drug responsiveness. Also, the prognostic role of MET indicates that anti-MET therapy is a very promising modality in adjuvant treatment for gastric cancer. British Journal of Cancer (2012) 107, 325-333. doi:10.1038/bjc.2012.237 www.bjcancer.com Published online 29 May 2012 (c) 2012 Cancer Research UK
ISSN
0007-0920
URI
https://hdl.handle.net/10371/172995
DOI
https://doi.org/10.1038/bjc.2012.237
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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