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Survival improvement with combined radio-chemotherapy in the primary central nervous system lymphomas

Cited 12 time in Web of Science Cited 12 time in Scopus
Authors
Wu, Hong Gyun; Kim, Il Han; Ha, Sung Whan; Park, Charn Il; Bang, Young Joo; Huh, Dae Seok
Issue Date
1999-10
Citation
Journal of Korean Medical Science, Vol.14 No.5, pp.565-570
Keywords
radiotherapydrug therapylymphomacentral nervous system
Abstract
The benefits of radio-chemotherapy in HIV-negative primary central nervous system (CNS) lymphomas were analyzed in 40 patients, who received radiotherapy to the brain or craniospinal axis with the total dose of 4460-5940 cGy to the primary tumor. Radiotherapy was followed by systemic chemotherapy, mainly with the cyclophospharmide, doxorubicin, vincristine and prednisolone (CHOP) regimen, in 16 of the patients. Follow-up ranged from four to 95 months with a median of 15 months. The relapse rate was 72.5%, and 83% of the relapses occurred within the radiation field. Median survival was 19 months and the two-year survival rate was 41%, Survival was significantly influenced by treatment method and radiation dose when measured by univariate analysis; median survival and the two-year survival rate was 29 months and 63% after radio-chemotherapy, while 13.5 month and 29% after radiotherapy alone (p=0.027), and 22 months and 49% with doses of 50 Gy or more, but 12.5 months and 13% with doses less than 50 Gy (p=0.009), However, statistical significance was lost in multivariate analysis. These results might suggest the short-term efficacy of radio-chemotherapy, however, cautious observation is needed to confirm long-term effects.
ISSN
1011-8934
URI
https://hdl.handle.net/10371/172999
DOI
https://doi.org/10.3346/jkms.1999.14.5.565
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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