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Prognostic significance of the expression of Smad4 and Smad7 in human gastric carcinomas

Cited 47 time in Web of Science Cited 63 time in Scopus
Authors
Kim, YH; Lee, HS; Lee, HJ; Hur, K; Kim, WH; Bang, Yung-Jue; Kim, SJ; Lee, KU; Choe, KJ; Yang, HK
Issue Date
2004-04
Citation
Annals of Oncology, Vol.15 No.4, pp.574-580
Keywords
gastric carcinomaprognostic factorSmad4Smad7transforming growth factor-beta
Abstract
Background: Transforming growth factor-beta (TGF-beta) modulates the growth and function of many cells, including those with malignant transformation. Smad proteins have been identified as major components in the intracellular signaling of TGF-beta family members. Patients and methods: To clarify the correlations between clinicopathologic profiles and the patient's survival, the expression of common mediator Smad (Smad4) and inhibitory Smad (Smad7) were evaluated immunohistochemically in 304 consecutive gastric carcinomas using the tissue array method. Results: Positive Smad4 expression was observed in 266 (87.5%) tumors and positive Smad7 expression in 98 (32.2%) tumors. The prognosis of patients with a Smad4-positive tumor was significantly better than that of the patients with a negative tumor. The survival rate was significantly higher in patients with negative Smad7 expression than those with positive Smad7 expression. In subgroup analysis according to TNM (tumour-node-metastasis) stage, both Smad4 and Smad7 showed most significant prognostic differences in stage I gastric cancer patients. Multivariate analysis indicated that tumor size, depth of invasion, lymph node metastasis and Smad7 expression were independent prognostic factors. Conclusion: Enhanced expression of the TGF-beta signaling inhibitor Smad7 may present one of the novel mechanisms of TGF-beta resistance in human gastric carcinomas.
ISSN
0923-7534
URI
https://hdl.handle.net/10371/173010
DOI
https://doi.org/10.1093/annonc/mdh131
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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