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Differing effects of adjuvant chemotherapy according to BRCA1 nuclear expression in gastric cancer

Cited 7 time in Web of Science Cited 10 time in Scopus
Authors
Kim, Jin Won; Cho, Hyun Jin; Kim, Miso; Lee, Kyung-Hun; Kim, Min A.; Han, Sae-Won; Oh, Do-Youn; Lee, Hyuk-Joon; Im, Seock-Ah; Kim, Tae-You; Yang, Han-Kwang; Kim, Woo Ho; Bang, Yung-Jue
Issue Date
2013-06
Citation
Cancer Chemotherapy and Pharmacology, Vol.71 No.6, pp.1435-1443
Keywords
BRCA1Nuclear expressAdjuvant chemotherapyGastric cancerPredictive marker
Abstract
We aimed to investigate the role of BRCA1 nuclear expression in sporadic gastric cancer; currently, the role remains unknown. Patients with gastric cancer who received curative operation with D2 dissection were enrolled in this study. Adjuvant chemotherapy was administered at the discretion of the physician. According to BRCA1 nuclear expression analysis by immunohistochemistry (IHC) on tissue microarrays using anti-BRCA1 antibody MS110, BRCA1 expression was classified as negative, low expression, and high expression. Among 318 cases, 155 cases (48.7 %) were identified as BRCA1-negative by IHC and 96 cases (30.2 %) revealed BRCA1 low expression, 67 cases (21.0 %) showed BRCA1 high expression. The negative or reduced expression of BRCA1 was more frequent in more advanced-stage disease (p < 0.001) and was associated with perineural invasion (p = 0.032). Disease-free survival (DFS) was significantly decreased with reduced BRCA1 expression (p = 0.027). This tendency was also observed in overall survival (OS), although the difference was not significant. The poorer prognosis of BRCA1-negative tumors was overcome through adjuvant chemotherapy. The benefit of adjuvant chemotherapy for DFS and OS in stage III was enhanced only in BRCA1-negative tumors (p < 0.001, p < 0.001, respectively), but not in BRCA1-positive tumors (p = 0.236, p = 0.148, respectively). The reduction of BRCA1 nuclear expression is associated with advanced stage and perineural invasion. Moreover, negative BRCA1 nuclear expression is a predictive marker regarding the benefit of adjuvant chemotherapy in sporadic gastric cancer; these novel findings are of great importance, and further, larger studies are warranted.
ISSN
0344-5704
URI
https://hdl.handle.net/10371/173023
DOI
https://doi.org/10.1007/s00280-013-2141-x
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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