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Adenovirus-uteroglobin suppresses COX-2 expression via inhibition of NF-κB activity in lung cancer cells : Adenovirus-uteroglobin suppresses COX-2 expression via inhibition of NF-kappa B activity in lung cancer cells
DC Field | Value | Language |
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dc.contributor.author | Yoon, Jung Min | - |
dc.contributor.author | Lim, Jae-Jun | - |
dc.contributor.author | Yoo, Chul-Gyu | - |
dc.contributor.author | Lee, Choon-Taek | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.contributor.author | Han, Sung Koo | - |
dc.contributor.author | Shim, Young-Soo | - |
dc.contributor.author | Kim, Young Whan | - |
dc.date.accessioned | 2021-01-31T11:06:16Z | - |
dc.date.available | 2021-01-31T11:06:16Z | - |
dc.date.created | 2020-12-23 | - |
dc.date.issued | 2005-05 | - |
dc.identifier.citation | Lung Cancer, Vol.48 No.2, pp.201-209 | - |
dc.identifier.issn | 0169-5002 | - |
dc.identifier.other | 119579 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173026 | - |
dc.description.abstract | Uteroglobin (UG, Clara cell secretory protein) is a steroid inducible, multifunctional protein that is secreted by the mucosal epithelia. UG has anti-proliferative and anti-metastatic effects in cancer cells. COX-2, which catalyzes the first step in the synthesis of prostanoids, has been shown to be overexpressed in tumors. This study investigated the effect of UG on the inhibition of COX-2 expression in lung cancer cells. The level of the COX-2 protein and its mRNA were decreased by UG, as demonstrated by Western Not and the RT-PCR, respectively. The EIA shows that UG suppressed PGE2 synthesis. Western blot showed that the NF-kappa B nuclear translocation was inhibited by the transduction of UG. In addition, an EMSA demonstrated the inhibition of the NF-kappa B-DNA binding by UG. The Luciferase assay showed that UG also inhibited the NF-kappa B-mediated transcription activity. Furthermore, transfection of the lung cancer cell lines with the COX-2 reporter gene constructs demonstrated that the transcription of COX-2 gene was suppressed by UG. These results show that the inhibition of COX-2 expression by UG transduction correlated with the suppression of NF-kappa B activity in the Lung cancer cells. This suggests that UG have the possibility for the treatment of lung cancer. (c) 2004 Published by Elsevier Ireland Ltd. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Adenovirus-uteroglobin suppresses COX-2 expression via inhibition of NF-κB activity in lung cancer cells | - |
dc.title.alternative | Adenovirus-uteroglobin suppresses COX-2 expression via inhibition of NF-kappa B activity in lung cancer cells | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.1016/j.lungcan.2004.11.005 | - |
dc.citation.journaltitle | Lung Cancer | - |
dc.identifier.wosid | 000228675300004 | - |
dc.identifier.scopusid | 2-s2.0-17044400171 | - |
dc.citation.endpage | 209 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 201 | - |
dc.citation.volume | 48 | - |
dc.identifier.sci | 000228675300004 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Yoo, Chul-Gyu | - |
dc.contributor.affiliatedAuthor | Lee, Choon-Taek | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.contributor.affiliatedAuthor | Kim, Young Whan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | HUMAN COLON-CANCER | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | TISSUE | - |
dc.subject.keywordPlus | LINES | - |
dc.subject.keywordAuthor | uterogtobin | - |
dc.subject.keywordAuthor | lung cancer | - |
dc.subject.keywordAuthor | COX-2 | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | adenovirus | - |
dc.subject.keywordAuthor | gene therapy | - |
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