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Expression of transforming growth factor β type II receptor reduces tumorigenicity in human gastric cancer cells : Expression of transforming growth factor beta type II receptor reduces tumorigenicity in human gastric cancer cells
DC Field | Value | Language |
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dc.contributor.author | Chang, Jay | - |
dc.contributor.author | Park, Keunchil | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.contributor.author | Kim, Won Seog | - |
dc.contributor.author | Kim, David | - |
dc.contributor.author | Kim, Seong-Jin | - |
dc.date.accessioned | 2021-01-31T11:06:33Z | - |
dc.date.available | 2021-01-31T11:06:33Z | - |
dc.date.created | 2020-12-23 | - |
dc.date.issued | 1997-07 | - |
dc.identifier.citation | Cancer Research, Vol.57 No.14, pp.2856-2859 | - |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.other | 119608 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173029 | - |
dc.description.abstract | Expression of transforming growth factor beta (TGF-beta) receptor type II (RII) is required for the growth-inhibitory effects of TGF-beta on proliferating epithelial cells, TGF-beta RII mutations have been identified in a broad spectrum of human epithelial malignancies, including colon and gastric cancers, and are highly correlated with development of TGF-beta resistance in cell lines derived from these tumors, In this study, the role of TGF-beta RII in regulating the tumorigenic potential of the SNU-638 human gastric cancer cell line was investigated by infecting these cells with retroviral construct (MFG) expressing TGF-beta RII, The SNU-638 cell line displays the DNA replication error phenotype and encodes a truncated, inactive TGF-beta RII protein, Infection of these cells with retroviral constructs expressing wild-type TGF-beta RII led to significant increases in TGF-beta RII mRNA and protein expression, These cells responded to exogenous TGF-beta with reduced proliferation compared to that of control cells infected with retroviral vector expressing chloramphenicol acetyltranferase. Addition of TGF-beta-neutralizing antibodies led to increased proliferation of wild-type TGF-beta RII-expressing SNU-638 cells but had no effect on control cells, The latter finding suggests that TGF-beta acts in an autocrine fashion to inhibit cell proliferation in SNU-638 cells, When transplanted into athymic nude mice, wild-type TGF-beta RII-expressing SNU-638 cells showed decreased and delayed tumorigenicity compared with control cells, This study suggests a strong association between the expression of wild-type TGF-beta RII and the degree of malignancy in human gastric cancer cells. | - |
dc.language | 영어 | - |
dc.publisher | American Association for Cancer Research | - |
dc.title | Expression of transforming growth factor β type II receptor reduces tumorigenicity in human gastric cancer cells | - |
dc.title.alternative | Expression of transforming growth factor beta type II receptor reduces tumorigenicity in human gastric cancer cells | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.citation.journaltitle | Cancer Research | - |
dc.identifier.wosid | A1997XL16200010 | - |
dc.identifier.scopusid | 2-s2.0-0030793369 | - |
dc.citation.endpage | 2859 | - |
dc.citation.number | 14 | - |
dc.citation.startpage | 2856 | - |
dc.citation.volume | 57 | - |
dc.identifier.sci | A1997XL16200010 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | TGF-BETA | - |
dc.subject.keywordPlus | MICROSATELLITE INSTABILITY | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | COLON | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | MUTATION | - |
dc.subject.keywordPlus | CLONING | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | KINASE | - |
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