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Effect of lapatinib on oral digoxin absorption in patients

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dc.contributor.authorKoch, Kevin M.-
dc.contributor.authorSmith, Deborah A.-
dc.contributor.authorBotbyl, Jeff-
dc.contributor.authorArya, Nikita-
dc.contributor.authorBriley, Linda P.-
dc.contributor.authorCartee, Leanne-
dc.contributor.authorWhite, Jane Holshouser-
dc.contributor.authorBeyer, Jennifer-
dc.contributor.authorDar, Mohammed M.-
dc.contributor.authorChung, Hyun Choel-
dc.contributor.authorChu, Quincy-
dc.contributor.authorBang, Yung-Jue-
dc.date.accessioned2021-01-31T11:08:34Z-
dc.date.available2021-01-31T11:08:34Z-
dc.date.issued2015-11-
dc.identifier.citationClinical Pharmacology in Drug Development, Vol.4 No.6, pp.449-453-
dc.identifier.issn2160-763X-
dc.identifier.other61720-
dc.identifier.urihttps://hdl.handle.net/10371/173053-
dc.description.abstractThe potential for an interaction between lapatinib and absorption of the P-glycoprotein (ABCB1) substrate digoxin at a therapeutic dose in breast cancer patients was characterized. Seventeen women with HER2-positive metastatic breast cancer received a single oral 0.5-mg dose of digoxin on days 1 and 9 and oral lapatinib 1500 mg once daily on days 2 through 9. Digoxin pharmacokinetic parameters were determined on day 1 (digoxin administration alone) and on day 9 (coadministration of lapatinib and digoxin), and parameters were compared to determine the effects of lapatinib on digoxin absorption. Concomitant medications that could affect ABCB1 were accounted for. Lapatinib 1500 mg/day increased digoxin absorption approximately 80%, implicating lapatinib inhibition of intestinal ABCB1-mediated efflux. In summary, coadministration of lapatinib with narrow therapeutic index drugs that are substrates of ABCB1 should be undertaken with caution and dose adjustment should be considered.-
dc.subjectlapatinib-
dc.subjectdigoxin-
dc.subjectdrug interaction-
dc.subjectp-glycoprotein-
dc.subjectABCB1-
dc.titleEffect of lapatinib on oral digoxin absorption in patients-
dc.typeArticle-
dc.contributor.AlternativeAuthor방영주-
dc.identifier.doi10.1002/cpdd.189-
dc.citation.journaltitleClinical Pharmacology in Drug Development-
dc.identifier.scopusid2-s2.0-84954218000-
dc.citation.endpage453-
dc.citation.number6-
dc.citation.startpage449-
dc.citation.volume4-
dc.identifier.urlhttps://accp1.onlinelibrary.wiley.com/doi/full/10.1002/cpdd.189-
dc.identifier.rimsid61720-
dc.identifier.sci000368922200007-
dc.contributor.affiliatedAuthorBang, Yung-Jue-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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