Browse

Cyclin E overexpression as an independent risk factor of visceral relapse in breast cancer

Cited 34 time in Web of Science Cited 36 time in Scopus
Authors
Kim, HK; Park, IA; Heo, DS; Noh, DY; Choe, KJ; Bang, Yung-Jue; Kim, NK
Issue Date
2001-08
Citation
European Journal of Surgical Oncology, Vol.27 No.5, pp.464-471
Keywords
breast cancercyclin Evisceral relapsepattern of relapse
Abstract
Aim: Prognostic value of the cyclin E overexpression in breast cancer has not been clearly established, especially in relation to the pattern of recurrence. We investigated the implication of cyclin E overexpression for the pattern of recurrence in Korean breast cancer patients. Methods: Using immunohistochemical methods, we retrospectively examined the cyclin E expression level in breast cancer specimens from 128 women who underwent curative breast surgery, and correlated the levels of expression with the pattern of relapse in patients. Results: Cox model-based multivariate analysis indicated that distant relapse could be predicted by the number of positive axillary lymph nodes, high cyclin E expression, and the younger age (< 35 years) of the patient. We tested further the association of cyclin E overexpression with the specific types of recurrence; multivariate analyses indicated that adjusted relative risks of bone and visceral relapse as the first events among high cyclin E group were 2.46 (95% confidence interval (CI), 0.86-7.02) (P = 0.092), and 3.98 (95% Cl, 1.23-12.94) (P = 0.022), respectively. On the other hand, cyclin E overexpression was not associated with the risk of locoregional relapse. Conclusion: Our data suggest that cyclin E overexpression in primary breast carcinoma tissue could independently predict the risk of distant relapse, especially of visceral relapse, as the first failure after curative breast surgery. (C) 2001 Harcourt Publishers Ltd.
ISSN
0748-7983
URI
https://hdl.handle.net/10371/173065
DOI
https://doi.org/10.1053/ejso.2001.1137
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse