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KEYNOTE-585: Phase III study of perioperative chemotherapy with or without pembrolizumab for gastric cancer

Cited 24 time in Web of Science Cited 22 time in Scopus
Authors
Bang, Yung-Jue; Van Cutsem, Eric; Fuchs, Charles S.; Ohtsu, Atsushi; Tabernero, Josep; Ilson, David H.; Hyung, Woo Jin; Strong, Vivian E.; Goetze, Thorsten Oliver; Yoshikawa, Takaki; Tang, Laura H.; Hwang, Peggy May Tan; Webb, Nancy; Adelberg, David; Shitara, Kohei
Issue Date
2019-03
Citation
Future Oncology, Vol.15 No.9, pp.943-952
Keywords
adjuvant therapychemotherapygastric cancergastroesophageal junction cancerimmunotherapyneoadjuvant therapypembrolizumabsurgery
Abstract
Background: Surgical resection is the only curative treatment option for gastric cancer. Despite widespread adoption of multimodality perioperative treatment strategies, 5-year overall survival rates remain low. In patients with advanced gastric or gastroesophageal junction adenocarcinoma, pembrolizumab has demonstrated promising efficacy and manageable safety as monotherapy in previously treated patients and as first-line therapy in combination with cisplatin and 5-fluorouracil. Combining chemotherapy with pembrolizumab in the neoadjuvant/adjuvant setting may benefit patients with locally advanced, resectable disease. Aim: To describe the design and rationale for the global, multicenter, randomized, double-blind, Phase III KEYNOTE-585 study to evaluate the efficacy and safety of pembrolizumab plus chemotherapy compared with placebo plus chemotherapy as neoadjuvant/adjuvant treatment for localized gastric or gastroesophageal junction adenocarcinoma. ClinicalTrials.gov: NCT03221426
ISSN
1479-6694
URI
https://hdl.handle.net/10371/173074
DOI
https://doi.org/10.2217/fon-2018-0581
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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