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Prognostic implication of antitumor immunity measured by the neutrophil-lymphocyte ratio and serum cytokines and angiogenic factors in gastric cancer

Cited 35 time in Web of Science Cited 37 time in Scopus
Authors
Ock, Chan-Young; Nam, Ah-Rong; Lee, Joongyub; Bang, Ju-Hee; Lee, Kyung-Hun; Han, Sae-Won; Kim, Tae-Yong; Im, Seock-Ah; Kim, Tae-You; Bang, Yung-Jue; Oh, Do-Youn
Issue Date
2017-03
Citation
Gastric Cancer, Vol.20 No.2, pp.254-262
Keywords
Neutrophil-lymphocyte ratioCytokinesAngiogenic factorsGastric cancerStromal-cell-derived factor 1
Abstract
The neutrophil-lymphocyte ratio (NLR) is associated with a poor prognosis in many cancers but the biological mechanisms involved are unknown. Since cytokines and angiogenic factors (CAFs) are reflected by various immune responses, we analyzed the association between the NLR and CAFs and their prognostic implications in gastric cancer (GC). Of 745 GC patients who were enrolled in NLR analysis, 70 underwent NLR and CAF association analyses. Pretreatment serum levels of 52 CAFs were measured by means of multiplex bead immunoassays and enzyme-linked immunosorbent assays. Linear regression analysis and survival analysis of the NLR with each CAF were performed. Metastatic organ numbers and carbohydrate antigen 19-9 levels were significantly higher in patients with a high NLR [greater than 2.42 (median): P = 0.047 and P < 0.001 respectively]. The overall survival was significantly worse in the high NLR group (17.8 months vs 11.2 months, P < 0.001). In CAF analysis, osteopontin (R (2) = 0.337, P < 0.001) and interleukin-6 (R (2) = 0.141, P = 0.001) were significantly associated with the NLR. Stromal-cell-derived factor 1 (SDF-1) was a significant poor prognostic factor independently of the NLR. Consideration of both the NLR and SDF-1 divided patient groups with different overall survival (both low, 21.0 months; either high, 15.8 months; both high, 8.2 months). The NLR is a significant poor prognostic factor in advanced GC. The NLR is mainly associated with osteopontin and interleukin-6. Besides the NLR, SDF-1 is an independent poor prognostic factor in GC. Consideration of both the NLR and SDF-1 might give insights into antitumor immunity in GC.
ISSN
1436-3291
URI
https://hdl.handle.net/10371/173081
DOI
https://doi.org/10.1007/s10120-016-0613-5
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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