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GC1118, a novel anti-EGFR antibody, has potent KRAS mutation-independent antitumor activity compared with cetuximab in gastric cancer
DC Field | Value | Language |
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dc.contributor.author | Park, Ji Eun | - |
dc.contributor.author | Jin, Mei Hua | - |
dc.contributor.author | Hur, Minkyu | - |
dc.contributor.author | Nam, Ah-Rong | - |
dc.contributor.author | Bang, Ju-Hee | - |
dc.contributor.author | Won, Jonghwa | - |
dc.contributor.author | Oh, Do-Youn | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.date.accessioned | 2021-01-31T11:10:54Z | - |
dc.date.available | 2021-01-31T11:10:54Z | - |
dc.date.created | 2019-09-27 | - |
dc.date.issued | 2019-09 | - |
dc.identifier.citation | Gastric Cancer, Vol.22 No.5, pp.932-940 | - |
dc.identifier.issn | 1436-3291 | - |
dc.identifier.other | 84639 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173085 | - |
dc.description.abstract | Background EGFR overexpression in gastric cancer (GC) has been reported in about 30% of patients. However, the anti-EGFR antibodies cetuximab and panitumumab have failed to improve overall survival of GC patients in combination with cytotoxic chemotherapy compared with chemotherapy alone. GC1118, a novel anti-EGFR antibody with a distinct binding epitope compared with cetuximab or panitumumab, has not been tested in GC. Methods GC cell lines, SNU-1, SNU-5, SNU-16, SNU-216, SNU-484, SNU-601, SNU-620, SNU-638, SNU-668, SNU-719, AGS, MKN-45, NCI-N87, and KATO-III, were employed to test the effect of cetuximab or GC1118 alone, and combined with the cytotoxic agent cisplatin or 5-fluorouracil (5-FU). Cells were also treat with or without high-affinity ligands EGF 20 ng/ml or HB-EGF 100 ng/ml. Results GC1118 exhibited a more potent growth inhibition effect in the majority of cell lines than cetuximab in MTT assay, regardless of the KRAS mutation status of cell lines. Co-treatment of GC1118 and cisplatin or 5-FU inhibited colony formation and migration to a greater extent, even following EGFR ligand stimulation. Ligand-induced p-AKT and p-ERK upregulation were more potently inhibited by combination treatment with GC1118 and chemotherapeutic agents compared with cetuximab plus chemotherapeutic agents. GC1118 also showed more potent anti-tumor effects compared with cetuximab in a mouse xenograft model. Conclusion Taken together, GC1118 alone or in combination with cytotoxic chemotherapeutic agents exerted more potent anti-tumor effects than cetuximab in GC cells, regardless of KRAS status. These findings support the further clinical development of GC1118 for the treatment of GC. | - |
dc.language | 영어 | - |
dc.publisher | Springer Verlag | - |
dc.title | GC1118, a novel anti-EGFR antibody, has potent KRAS mutation-independent antitumor activity compared with cetuximab in gastric cancer | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.1007/s10120-019-00943-x | - |
dc.citation.journaltitle | Gastric Cancer | - |
dc.identifier.wosid | 000481429600003 | - |
dc.identifier.scopusid | 2-s2.0-85062493863 | - |
dc.citation.endpage | 940 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 932 | - |
dc.citation.volume | 22 | - |
dc.identifier.sci | 000481429600003 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Oh, Do-Youn | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | GROWTH-FACTOR RECEPTOR | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | CAPECITABINE | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordAuthor | EGFR | - |
dc.subject.keywordAuthor | GC1118 | - |
dc.subject.keywordAuthor | Cetuximab | - |
dc.subject.keywordAuthor | Gastric cancer | - |
dc.subject.keywordAuthor | KRAS | - |
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