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Expression of cyclooxygenase-2 in association with clinicopathological prognostic factors and molecular markers in epithelial ovarian cancer
DC Field | Value | Language |
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dc.contributor.author | Seo, Sang Soo | - |
dc.contributor.author | Song, Yong Sang | - |
dc.contributor.author | Kang, Dae-hee | - |
dc.contributor.author | Park, In Ae | - |
dc.contributor.author | Bang, Yung Jue | - |
dc.contributor.author | Kang, Soon Beom | - |
dc.contributor.author | Lee, Hyo Pyo | - |
dc.date.accessioned | 2021-01-31T11:11:18Z | - |
dc.date.available | 2021-01-31T11:11:18Z | - |
dc.date.created | 2018-04-11 | - |
dc.date.issued | 2004-03 | - |
dc.identifier.citation | Gynecologic Oncology, Vol.92 No.3, pp.927-935 | - |
dc.identifier.issn | 0090-8258 | - |
dc.identifier.other | 31974 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173091 | - |
dc.description.abstract | Objectives. This study examines whether expression of COX-2 is associated with clinicopathological features and other molecular markers of ovarian cancer. Methods. Sixty-four paraffin-embedded tissue specimens were obtained from patients with ovarian cancer who received cytoreductive surgery and combination chemotherapy. Tissue specimens were subjected to immunohistochemical analysis using antibodies to COX-2, p53, and VEGF. Results. Increased COX-2 expression significantly correlated with histologic type (mucinous 5.6% vs. non-mucinous 65.2%, P < 0.001). COX-2 expression was also significantly associated with stage, tumor grade, residual disease status, and presence of ascites. COX-2 expression correlated positively with expression of p53 (P = 0.006) and VEGF (P = 0.025). Although survival was lower in patients with high COX-2 expression than in those without high COX-2 expression (P < 0.001), only tumor grade and stage were independent prognostic indicators. In patients with non-mucinous cancer, COX-2 expression correlated with stage (P < 0.001) and presence of ascites (P = 0.033). Conclusions. Our results suggest that expression of COX-2 in ovarian cancers is specific to histologic type of tumor and is associated with poor clinicopathologic prognostic factors. Expression of COX-2 also correlates well with expression of p53 and VEGF. (C) 2004 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Academic Press | - |
dc.title | Expression of cyclooxygenase-2 in association with clinicopathological prognostic factors and molecular markers in epithelial ovarian cancer | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.1016/j.ygyno.2003.11.055 | - |
dc.citation.journaltitle | Gynecologic Oncology | - |
dc.identifier.wosid | 000220057700029 | - |
dc.identifier.scopusid | 2-s2.0-1342321831 | - |
dc.citation.endpage | 935 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 927 | - |
dc.citation.volume | 92 | - |
dc.identifier.sci | 000220057700029 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Song, Yong Sang | - |
dc.contributor.affiliatedAuthor | Kang, Dae-hee | - |
dc.contributor.affiliatedAuthor | Park, In Ae | - |
dc.contributor.affiliatedAuthor | Bang, Yung Jue | - |
dc.contributor.affiliatedAuthor | Kang, Soon Beom | - |
dc.contributor.affiliatedAuthor | Lee, Hyo Pyo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | - |
dc.subject.keywordPlus | PLATINUM-BASED CHEMOTHERAPY | - |
dc.subject.keywordPlus | GROWTH-FACTOR EXPRESSION | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | CELL LUNG-CANCER | - |
dc.subject.keywordPlus | P53 MUTATIONS | - |
dc.subject.keywordPlus | TUMOR INVASIVENESS | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | GASTRIC-CARCINOMA | - |
dc.subject.keywordPlus | VEGF EXPRESSION | - |
dc.subject.keywordAuthor | COX-2 | - |
dc.subject.keywordAuthor | p53 | - |
dc.subject.keywordAuthor | VEGF | - |
dc.subject.keywordAuthor | epithelial ovarian cancer | - |
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