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Therapeutic plasma exchange in patients with thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: The 10-year experience of a single center

Cited 5 time in Web of Science Cited 6 time in Scopus
Authors
Kim, Ji-Won; Kim, Inho; Oh, Kook-Hwan; Yoon, Sung-Soo; Oh, Myoung-Don; Song, Yeong Wook; Heo, Dae Seog; Bang, Yung-Jue; Han, Kyou-Sup; Han, Jin Suk; Park, Seonyang; Kim, Byoung Kook
Issue Date
2011-03
Citation
Hematology, Vol.16 No.2, pp.73-79
Keywords
Thrombotic thrombocytopenic purpuraHemolytic uremic syndromeThrombotic microangiopathyTherapeutic plasma exchange
Abstract
Background: Therapeutic plasma exchange (TPE) has been used for the treatment of patients with thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS). We report the 10-year treatment results along with the risk factors analyses. Methods: Retrospective analyses were performed on patients who were treated with TPE for TTP-HUS. Results: Fifty-two patients were included. Secondary causes were identified in 38 patients (73.1%). The others were classified as idiopathic. After a median five sessions of TPE, 26 patients (50.0%) achieved remission. Remission rate in patients with idiopathic and secondary TTP-HUS was 71.4 and 42.1%, respectively. Overall 30-day mortality rate was 34.6% and median overall survival was 5.2 months. Patients with hematopoietic stem cell transplantation-associated TTP-HUS did not respond and had poor overall survival. Males had a lower remission rate than females (P=0.009). Conclusions: TPE was an effective treatment in patients with idiopathic TTP-HUS. Treatment results were various according to etiology and gender.
ISSN
1024-5332
URI
https://hdl.handle.net/10371/173093
DOI
https://doi.org/10.1179/102453311X12902908411995
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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