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S-1-induced lacrimal drainage obstruction and its association with ingredients/metabolites of S-1 in tears and plasma: A prospective multi-institutional study
DC Field | Value | Language |
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dc.contributor.author | Kim, Namju | - |
dc.contributor.author | Kim, Jin Won | - |
dc.contributor.author | Baek, Je-Hyun | - |
dc.contributor.author | Kim, Jin-Soo | - |
dc.contributor.author | Choung, Ho-Kyung | - |
dc.contributor.author | Kim, Tae-Yong | - |
dc.contributor.author | Lee, Kyung-Hun | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.contributor.author | Khwarg, Sang In | - |
dc.contributor.author | Ahn, Sang-Hoon | - |
dc.contributor.author | Park, Do Joong | - |
dc.contributor.author | Kim, Hyung-Ho | - |
dc.contributor.author | Chung, Jae-Yong | - |
dc.contributor.author | Ahn, Soyeon | - |
dc.contributor.author | Lee, Keun-Wook | - |
dc.date.accessioned | 2021-01-31T11:11:31Z | - |
dc.date.available | 2021-01-31T11:11:31Z | - |
dc.date.created | 2018-12-14 | - |
dc.date.issued | 2018-01 | - |
dc.identifier.citation | Cancer Research and Treatment, Vol.50 No.1, pp.30-39 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.other | 71198 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173094 | - |
dc.description.abstract | Purpose This prospective study was conducted to determine the incidence of lacrimal drainage obstruction (LDO) during S-1 chemotherapy and evaluate the association between the development of LDO and the concentrations of ingredients/metabolites of S-1 in tears and plasma. Materials and Methods A total of 145 patients with gastric cancer who received adjuvant S-1 therapy were enrolled. Ophthalmologic examinations were performed regularly during S-1 chemotherapy. Concentrations of tegafur, 5-chloro-2,4-dihydroxypyridine (CDHP), and 5-fluorouracil at steady-state trough level were measured in both tears and plasma. Results Fifty-three patients (37%) developed LDO. The median time to the onset of LDO was 10.9 weeks, and LDO developed most frequently in the nasolacrimal duct. Univariable analyses revealed that an older age (>= 70 years), creatinine clearance rate (Ccr) < 80 mL/min, 5-fluorouracil concentration in plasma >= 22.3 ng/mL (median), CDHP concentration in plasma >= 42.0 ng/mL (median), and tegafur concentration in tears >= 479.2 ng/mL (median) were related to increased development of LDO. Multivariable analysis indicated that a high plasma 5-fluorouracil concentration was predictive of increased development of LDO (hazard ratio, 2.02; p=0.040), along with older age and decreased Ccr. Patients with LDO also developed S-1-related non-hematologic toxicity more frequently than those without LDO (p=0.016). Conclusion LDO is a frequent adverse event during S-1 chemotherapy. An older age, decreased Ccr, and high plasma 5-fluorouracil concentration were found to be independent risk factors for LDO. The high incidence of LDO warrants regular ophthalmologic examination and early intervention in patients receiving S-1 therapy. | - |
dc.language | 영어 | - |
dc.publisher | 대한암학회 | - |
dc.title | S-1-induced lacrimal drainage obstruction and its association with ingredients/metabolites of S-1 in tears and plasma: A prospective multi-institutional study | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.4143/crt.2016.569 | - |
dc.citation.journaltitle | Cancer Research and Treatment | - |
dc.identifier.wosid | 000422912900004 | - |
dc.identifier.scopusid | 2-s2.0-85040440275 | - |
dc.citation.endpage | 39 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 30 | - |
dc.citation.volume | 50 | - |
dc.identifier.sci | 000422912900004 | - |
dc.identifier.kciid | ART002308062 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Choung, Ho-Kyung | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.contributor.affiliatedAuthor | Khwarg, Sang In | - |
dc.contributor.affiliatedAuthor | Kim, Hyung-Ho | - |
dc.contributor.affiliatedAuthor | Chung, Jae-Yong | - |
dc.contributor.affiliatedAuthor | Lee, Keun-Wook | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ORAL ANTICANCER DRUG | - |
dc.subject.keywordPlus | OUTFLOW MECHANISM | - |
dc.subject.keywordPlus | GASTRIC-CANCER | - |
dc.subject.keywordPlus | 5-FLUOROURACIL | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | DUCTS | - |
dc.subject.keywordAuthor | Lacrimal drainage obstruction | - |
dc.subject.keywordAuthor | S-1 | - |
dc.subject.keywordAuthor | Fluorouracil | - |
dc.subject.keywordAuthor | Tears | - |
dc.subject.keywordAuthor | Stomach neoplasms | - |
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