Publications

Detailed Information

Heterogeneous amplification of ERBB2 in primary lesions is responsible for the discordant ERBB2 status of primary and metastatic lesions in gastric carcinoma

DC Field Value Language
dc.contributor.authorKim, Min A.-
dc.contributor.authorLee, Hyuk-Joon-
dc.contributor.authorYang, Han-Kwang-
dc.contributor.authorBang, Yung-Jue-
dc.contributor.authorKim, Woo Ho-
dc.date.accessioned2021-01-31T11:11:35Z-
dc.date.available2021-01-31T11:11:35Z-
dc.date.created2020-12-23-
dc.date.issued2011-11-
dc.identifier.citationHistopathology, Vol.59 No.5, pp.822-831-
dc.identifier.issn0309-0167-
dc.identifier.other119686-
dc.identifier.urihttps://hdl.handle.net/10371/173095-
dc.description.abstractAims: To determine the extent of HER2 homogeneity/heterogeneity in primary versus metastatic gastric carcinoma ( GC). Materials and results: The human epidermal growth factor receptor 2 ( HER2) status in primary and metastatic lesions was evaluated by immunohistochemistry ( IHC) and fluorescence in-situ hybridization ( FISH). Four separate cohorts consisting of primary GC alone or primary GC paired with metastatic lesions were examined. In the FISH analysis of 325 primary GCs, eight cases ( 2.5%) showed amplification with a heterogeneous pattern, whereas 27 cases ( 8.3%) showed amplification with a homogeneous pattern, and in this cohort the discordant: concordant FISH ratio based on examination of three different areas in each primary lesion was 0.30: 1. FISH testing using 250 paired primary and metastatic lesions revealed seven cases (2.8%) with discordant amplification. In metastatic disease positive conversion occurred in six cases (2.4%), whereas negative conversion happened in one case (0.4%). The discordant: concordant ratio of primary versus secondary lesions was 0.23: 1. When the seven discordant cases were re-evaluated using whole sections of primary GCs, six showed a heterogeneous pattern of amplification. Conclusions: These findings suggest that the discordant HER2 amplification observed in metastatic lesions is explained substantially by heterogeneity within primary tumours.-
dc.language영어-
dc.publisherBlackwell Publishing Inc.-
dc.titleHeterogeneous amplification of ERBB2 in primary lesions is responsible for the discordant ERBB2 status of primary and metastatic lesions in gastric carcinoma-
dc.typeArticle-
dc.contributor.AlternativeAuthor방영주-
dc.identifier.doi10.1111/j.1365-2559.2011.04012.x-
dc.citation.journaltitleHistopathology-
dc.identifier.wosid000297244900002-
dc.identifier.scopusid2-s2.0-81555209828-
dc.citation.endpage831-
dc.citation.number5-
dc.citation.startpage822-
dc.citation.volume59-
dc.identifier.sci000297244900002-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorLee, Hyuk-Joon-
dc.contributor.affiliatedAuthorYang, Han-Kwang-
dc.contributor.affiliatedAuthorBang, Yung-Jue-
dc.contributor.affiliatedAuthorKim, Woo Ho-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusIN-SITU HYBRIDIZATION-
dc.subject.keywordPlusPRIMARY BREAST-CANCER-
dc.subject.keywordPlusGROWTH-FACTOR RECEPTOR-
dc.subject.keywordPlusHER-2 STATUS-
dc.subject.keywordPlusADJUVANT CHEMOTHERAPY-
dc.subject.keywordPlusMONOCLONAL-ANTIBODY-
dc.subject.keywordPlusGENE AMPLIFICATION-
dc.subject.keywordPlusC-ERBB-2 GENE-
dc.subject.keywordPlusTRASTUZUMAB-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordAuthorfluorescence in-situ hybridization-
dc.subject.keywordAuthorHER2-
dc.subject.keywordAuthorimmunohistochemistry-
dc.subject.keywordAuthorstomach neoplasm-
dc.subject.keywordAuthortissue array analysis-
Appears in Collections:
Files in This Item:
There are no files associated with this item.

Related Researcher

  • College of Medicine
  • Department of Medicine
Research Area Clinical Medicine

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share