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Heterogeneous amplification of ERBB2 in primary lesions is responsible for the discordant ERBB2 status of primary and metastatic lesions in gastric carcinoma

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dc.contributor.authorKim, Min A.-
dc.contributor.authorLee, Hyuk-Joon-
dc.contributor.authorYang, Han-Kwang-
dc.contributor.authorBang, Yung-Jue-
dc.contributor.authorKim, Woo Ho-
dc.date.accessioned2021-01-31T11:11:35Z-
dc.date.available2021-01-31T11:11:35Z-
dc.date.issued2011-11-
dc.identifier.citationHistopathology, Vol.59 No.5, pp.822-831-
dc.identifier.issn0309-0167-
dc.identifier.other119686-
dc.identifier.urihttps://hdl.handle.net/10371/173095-
dc.description.abstractAims: To determine the extent of HER2 homogeneity/heterogeneity in primary versus metastatic gastric carcinoma ( GC). Materials and results: The human epidermal growth factor receptor 2 ( HER2) status in primary and metastatic lesions was evaluated by immunohistochemistry ( IHC) and fluorescence in-situ hybridization ( FISH). Four separate cohorts consisting of primary GC alone or primary GC paired with metastatic lesions were examined. In the FISH analysis of 325 primary GCs, eight cases ( 2.5%) showed amplification with a heterogeneous pattern, whereas 27 cases ( 8.3%) showed amplification with a homogeneous pattern, and in this cohort the discordant: concordant FISH ratio based on examination of three different areas in each primary lesion was 0.30: 1. FISH testing using 250 paired primary and metastatic lesions revealed seven cases (2.8%) with discordant amplification. In metastatic disease positive conversion occurred in six cases (2.4%), whereas negative conversion happened in one case (0.4%). The discordant: concordant ratio of primary versus secondary lesions was 0.23: 1. When the seven discordant cases were re-evaluated using whole sections of primary GCs, six showed a heterogeneous pattern of amplification. Conclusions: These findings suggest that the discordant HER2 amplification observed in metastatic lesions is explained substantially by heterogeneity within primary tumours.-
dc.subjectfluorescence in-situ hybridization-
dc.subjectHER2-
dc.subjectimmunohistochemistry-
dc.subjectstomach neoplasm-
dc.subjecttissue array analysis-
dc.titleHeterogeneous amplification of ERBB2 in primary lesions is responsible for the discordant ERBB2 status of primary and metastatic lesions in gastric carcinoma-
dc.typeArticle-
dc.contributor.AlternativeAuthor방영주-
dc.identifier.doi10.1111/j.1365-2559.2011.04012.x-
dc.citation.journaltitleHistopathology-
dc.identifier.scopusid2-s2.0-81555209828-
dc.citation.endpage831-
dc.citation.number5-
dc.citation.startpage822-
dc.citation.volume59-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1111/j.1365-2559.2011.04012.x-
dc.identifier.rimsid119686-
dc.identifier.sci000297244900002-
dc.contributor.affiliatedAuthorBang, Yung-Jue-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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