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Heterogeneous amplification of ERBB2 in primary lesions is responsible for the discordant ERBB2 status of primary and metastatic lesions in gastric carcinoma
DC Field | Value | Language |
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dc.contributor.author | Kim, Min A. | - |
dc.contributor.author | Lee, Hyuk-Joon | - |
dc.contributor.author | Yang, Han-Kwang | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.contributor.author | Kim, Woo Ho | - |
dc.date.accessioned | 2021-01-31T11:11:35Z | - |
dc.date.available | 2021-01-31T11:11:35Z | - |
dc.date.created | 2020-12-23 | - |
dc.date.issued | 2011-11 | - |
dc.identifier.citation | Histopathology, Vol.59 No.5, pp.822-831 | - |
dc.identifier.issn | 0309-0167 | - |
dc.identifier.other | 119686 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173095 | - |
dc.description.abstract | Aims: To determine the extent of HER2 homogeneity/heterogeneity in primary versus metastatic gastric carcinoma ( GC). Materials and results: The human epidermal growth factor receptor 2 ( HER2) status in primary and metastatic lesions was evaluated by immunohistochemistry ( IHC) and fluorescence in-situ hybridization ( FISH). Four separate cohorts consisting of primary GC alone or primary GC paired with metastatic lesions were examined. In the FISH analysis of 325 primary GCs, eight cases ( 2.5%) showed amplification with a heterogeneous pattern, whereas 27 cases ( 8.3%) showed amplification with a homogeneous pattern, and in this cohort the discordant: concordant FISH ratio based on examination of three different areas in each primary lesion was 0.30: 1. FISH testing using 250 paired primary and metastatic lesions revealed seven cases (2.8%) with discordant amplification. In metastatic disease positive conversion occurred in six cases (2.4%), whereas negative conversion happened in one case (0.4%). The discordant: concordant ratio of primary versus secondary lesions was 0.23: 1. When the seven discordant cases were re-evaluated using whole sections of primary GCs, six showed a heterogeneous pattern of amplification. Conclusions: These findings suggest that the discordant HER2 amplification observed in metastatic lesions is explained substantially by heterogeneity within primary tumours. | - |
dc.language | 영어 | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Heterogeneous amplification of ERBB2 in primary lesions is responsible for the discordant ERBB2 status of primary and metastatic lesions in gastric carcinoma | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.1111/j.1365-2559.2011.04012.x | - |
dc.citation.journaltitle | Histopathology | - |
dc.identifier.wosid | 000297244900002 | - |
dc.identifier.scopusid | 2-s2.0-81555209828 | - |
dc.citation.endpage | 831 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 822 | - |
dc.citation.volume | 59 | - |
dc.identifier.sci | 000297244900002 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Lee, Hyuk-Joon | - |
dc.contributor.affiliatedAuthor | Yang, Han-Kwang | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.contributor.affiliatedAuthor | Kim, Woo Ho | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | IN-SITU HYBRIDIZATION | - |
dc.subject.keywordPlus | PRIMARY BREAST-CANCER | - |
dc.subject.keywordPlus | GROWTH-FACTOR RECEPTOR | - |
dc.subject.keywordPlus | HER-2 STATUS | - |
dc.subject.keywordPlus | ADJUVANT CHEMOTHERAPY | - |
dc.subject.keywordPlus | MONOCLONAL-ANTIBODY | - |
dc.subject.keywordPlus | GENE AMPLIFICATION | - |
dc.subject.keywordPlus | C-ERBB-2 GENE | - |
dc.subject.keywordPlus | TRASTUZUMAB | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | fluorescence in-situ hybridization | - |
dc.subject.keywordAuthor | HER2 | - |
dc.subject.keywordAuthor | immunohistochemistry | - |
dc.subject.keywordAuthor | stomach neoplasm | - |
dc.subject.keywordAuthor | tissue array analysis | - |
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