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OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kim, Mi-Jung | - |
| dc.contributor.author | Nam, Hyun-Jin | - |
| dc.contributor.author | Kim, Hwang-Phill | - |
| dc.contributor.author | Han, Sae-Won | - |
| dc.contributor.author | Im, Seock-Ah | - |
| dc.contributor.author | Kim, Tae-You | - |
| dc.contributor.author | Oh, Do-Youn | - |
| dc.contributor.author | Bang, Yung-Jue | - |
| dc.date.accessioned | 2021-01-31T11:12:08Z | - |
| dc.date.available | 2021-01-31T11:12:08Z | - |
| dc.date.created | 2020-12-21 | - |
| dc.date.created | 2020-12-21 | - |
| dc.date.created | 2020-12-21 | - |
| dc.date.created | 2020-12-21 | - |
| dc.date.issued | 2013-07 | - |
| dc.identifier.citation | Cancer Letters, Vol.335 No.1, pp.145-152 | - |
| dc.identifier.issn | 0304-3835 | - |
| dc.identifier.other | 119340 | - |
| dc.identifier.uri | https://hdl.handle.net/10371/173104 | - |
| dc.description.abstract | We investigated the mechanisms of action and antitumor effects of OPB-31121, a novel STAT3 inhibitor, in gastric cancer cells. OPB-31121 downregulated JAK2 and gp130 expression and inhibited JAK2 phosphorylation which leads to inhibition of STAT3 phosphorylation. OPB-31121 inhibited constitutively activated and IL-6-induced JAK/STAT signaling pathway. OPB-31121 decreased cell proliferation in both gastric cancer cells and in a xenograft model, induced the apoptosis of gastric cancer cells, inhibited the expression of antiapoptotic proteins, and showed synergism with 5-fluorouracil and cisplatin. Taken together, our study suggests that STAT3 inhibition with OPB-31121 can be tested in patients with gastric cancer. (c) 2013 Elsevier Ireland Ltd. All rights reserved. | - |
| dc.language | 영어 | - |
| dc.publisher | Elsevier BV | - |
| dc.title | OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells | - |
| dc.type | Article | - |
| dc.contributor.AlternativeAuthor | 임석아 | - |
| dc.identifier.doi | 10.1016/j.canlet.2013.02.010 | - |
| dc.citation.journaltitle | Cancer Letters | - |
| dc.identifier.wosid | 000323853200018 | - |
| dc.identifier.scopusid | 2-s2.0-84878432714 | - |
| dc.citation.endpage | 152 | - |
| dc.citation.number | 1 | - |
| dc.citation.startpage | 145 | - |
| dc.citation.volume | 335 | - |
| dc.identifier.sci | 000323853200018 | - |
| dc.description.isOpenAccess | N | - |
| dc.contributor.affiliatedAuthor | Im, Seock-Ah | - |
| dc.contributor.affiliatedAuthor | Kim, Tae-You | - |
| dc.contributor.affiliatedAuthor | Oh, Do-Youn | - |
| dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
| dc.type.docType | Article | - |
| dc.description.journalClass | 1 | - |
| dc.subject.keywordPlus | ACTIVATED SIGNAL TRANSDUCER | - |
| dc.subject.keywordPlus | HUMAN MYELOMA CELLS | - |
| dc.subject.keywordPlus | CONSTITUTIVE ACTIVATION | - |
| dc.subject.keywordPlus | CONFERS RESISTANCE | - |
| dc.subject.keywordPlus | KINASE INHIBITOR | - |
| dc.subject.keywordPlus | STAT3 ACTIVATION | - |
| dc.subject.keywordPlus | EXPRESSION | - |
| dc.subject.keywordPlus | APOPTOSIS | - |
| dc.subject.keywordPlus | TRANSCRIPTION-3 | - |
| dc.subject.keywordPlus | GP130 | - |
| dc.subject.keywordAuthor | OPB-31121 | - |
| dc.subject.keywordAuthor | Gastric cancer | - |
| dc.subject.keywordAuthor | STAT3 | - |
| dc.subject.keywordAuthor | JAK2 | - |
| dc.subject.keywordAuthor | IL-6 | - |
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