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Mechanism-based model characterizing bidirectional interaction between PEGylated liposomal CKD-602 (S-CKD602) and monocytes in cancer patients
DC Field | Value | Language |
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dc.contributor.author | Wu, Huali | - |
dc.contributor.author | Ramanathan, Ramesh K. | - |
dc.contributor.author | Zamboni, Beth A. | - |
dc.contributor.author | Strychor, Sandra | - |
dc.contributor.author | Ramalingam, Suresh | - |
dc.contributor.author | Edwards, Robert P. | - |
dc.contributor.author | Friedland, David M. | - |
dc.contributor.author | Stoller, Ronald G. | - |
dc.contributor.author | Belani, Chandra P. | - |
dc.contributor.author | Maruca, Lauren J. | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.contributor.author | Zamboni, William C. | - |
dc.date.accessioned | 2021-01-31T11:53:50Z | - |
dc.date.available | 2021-01-31T11:53:50Z | - |
dc.date.created | 2020-07-29 | - |
dc.date.issued | 2012-07 | - |
dc.identifier.citation | International journal of nanomedicine, Vol.7, pp.5555-5564 | - |
dc.identifier.issn | 1176-9114 | - |
dc.identifier.other | 109399 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173115 | - |
dc.description.abstract | S-CKD602 is a PEGylated liposomal formulation of CKD-602, a potent topoisomerase I inhibitor. The objective of this study was to characterize the bidirectional pharmacokinetic-pharmacodynamic (PK-PD) interaction between S-CKD602 and monocytes. Plasma concentrations of encapsulated CKD-602 and monocytes counts from 45 patients with solid tumors were collected following intravenous administration of S-CKD602 in the phase I study. The PK-PD models were developed and fit simultaneously to the PK-PD data, using NONMEM (R). The monocytopenia after administration of S-CKD602 was described by direct toxicity to monocytes in a mechanism-based model, and by direct toxicity to progenitor cells in bone marrow in a myelosuppression-based model. The nonlinear PK disposition of S-CKD602 was described by linear degradation and irreversible binding to monocytes in the mechanism-based model, and Michaelis-Menten kinetics in the myelosuppression-based model. The mechanism-based PK-PD model characterized the nonlinear PK disposition, and the bidirectional PK-PD interaction between S-CKD602 and monocytes. | - |
dc.language | 영어 | - |
dc.publisher | Dove Medical Press Ltd | - |
dc.title | Mechanism-based model characterizing bidirectional interaction between PEGylated liposomal CKD-602 (S-CKD602) and monocytes in cancer patients | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.2147/IJN.S35751 | - |
dc.citation.journaltitle | International journal of nanomedicine | - |
dc.identifier.wosid | 000309954800001 | - |
dc.identifier.scopusid | 2-s2.0-84870352919 | - |
dc.citation.endpage | 5564 | - |
dc.citation.startpage | 5555 | - |
dc.citation.volume | 7 | - |
dc.identifier.sci | 000309954800001 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ANTICANCER AGENTS | - |
dc.subject.keywordPlus | PHASE-I | - |
dc.subject.keywordPlus | PHARMACOKINETIC PARAMETERS | - |
dc.subject.keywordPlus | PHARMACODYNAMIC MODEL | - |
dc.subject.keywordPlus | ADVANCED MALIGNANCIES | - |
dc.subject.keywordPlus | LUNG-CANCER | - |
dc.subject.keywordPlus | TIME-COURSE | - |
dc.subject.keywordPlus | NEUTROPENIA | - |
dc.subject.keywordPlus | DRUGS | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordAuthor | population pharmacokinetics | - |
dc.subject.keywordAuthor | pharmacodynamics | - |
dc.subject.keywordAuthor | PEGylated liposome | - |
dc.subject.keywordAuthor | nonlinear kinetics | - |
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