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Phase I study of weekly docetaxel and cisplatin concurrent with thoracic radiotherapy in stage III non-small-cell lung cancer
DC Field | Value | Language |
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dc.contributor.author | Wu, Hong Gyun | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.contributor.author | Choi, Eun Kyung | - |
dc.contributor.author | Ahn, Yong Chan | - |
dc.contributor.author | Kim, Young Whan | - |
dc.contributor.author | Lim, Tae-Hwan | - |
dc.contributor.author | Suh, Cheolwon | - |
dc.contributor.author | Park, Keunchil | - |
dc.contributor.author | Park, Charn Il | - |
dc.date.accessioned | 2021-01-31T11:54:49Z | - |
dc.date.available | 2021-01-31T11:54:49Z | - |
dc.date.created | 2020-12-23 | - |
dc.date.issued | 2002-01 | - |
dc.identifier.citation | International Journal of Radiation Oncology Biology Physics, Vol.52 No.1, pp.75-80 | - |
dc.identifier.issn | 0360-3016 | - |
dc.identifier.other | 119638 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173129 | - |
dc.description.abstract | Purpose: This is the first report of a Phase I study on concomitant weekly cisplatin and docetaxel chemotherapy with thoracic radiation for Stage III non-small-cell lung cancer (NSCLC). The study objectives were to determine the maximum tolerable dose (MTD) and dose-limiting toxicity (DLT) of docetaxel used in this regimen, and to evaluate the feasibility of weekly concurrent chemoradiotherapy. Methods and Materials: Patients with histologically proven and unresectable Stage III NSCLC were the subjects of this study. Cisplatin was administered at a fixed dose of 20 mg/m(2), while the dose of docetaxel was increased from 0 to 30 mg/m(2) in increments of 10 mg/m(2). Chemotherapy was given on the first day of each week for 6 weeks. The primary tumor and regional lymph nodes were irradiated to 54 Gy, followed by an additional 9 Gy boost to the primary tumor, making the total dose 63 Gy at 1.8 Gy/fraction. Results: Sixteen men and 2 women with advanced NSCLC without prior treatment were enrolled. The median age of the group was 58 years (range 49-67). Three patients had Stage IIIa disease and 15 patients had IIIb disease. Dose-limiting Grade 3 esophagitis was encountered at a docetaxel dose level of 30 mg/m2 in 2 of 3 patients. No dose-limiting, nonhematologic toxicity occurred in the other patients and no dose-limiting hematologic toxicity occurred in any patient. Conclusion: The treatment schedule for NSCLC was feasible, with the DLT being esophagitis. We determined the recommended dose of docetaxel to be 20 mg/m(2) for a Phase II study when combined with weekly cisplatin and concomitant thoracic RT. (C) 2002 Elsevier Science Inc. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Phase I study of weekly docetaxel and cisplatin concurrent with thoracic radiotherapy in stage III non-small-cell lung cancer | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.1016/S0360-3016(01)01739-4 | - |
dc.citation.journaltitle | International Journal of Radiation Oncology Biology Physics | - |
dc.identifier.wosid | 000173105100010 | - |
dc.identifier.scopusid | 2-s2.0-0036139019 | - |
dc.citation.endpage | 80 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 75 | - |
dc.citation.volume | 52 | - |
dc.identifier.sci | 000173105100010 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Wu, Hong Gyun | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.contributor.affiliatedAuthor | Kim, Young Whan | - |
dc.contributor.affiliatedAuthor | Park, Charn Il | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | RADIATION-THERAPY | - |
dc.subject.keywordPlus | RANDOMIZED TRIAL | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | PACLITAXEL | - |
dc.subject.keywordPlus | TAXOTERE | - |
dc.subject.keywordPlus | TAXOL | - |
dc.subject.keywordAuthor | non-small-cell lung cancer | - |
dc.subject.keywordAuthor | combined chemotherapy and radiotherapy | - |
dc.subject.keywordAuthor | docetaxel | - |
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