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Bidirectional pharmacodynamic interaction between pegylated liposomal CKD-602 (S-CKD602) and monocytes in patients with refractory solid tumors
DC Field | Value | Language |
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dc.contributor.author | Zamboni, William C. | - |
dc.contributor.author | Maruca, Lauren J. | - |
dc.contributor.author | Strychor, Sandra | - |
dc.contributor.author | Zamboni, Beth A. | - |
dc.contributor.author | Ramalingam, Suresh | - |
dc.contributor.author | Edwards, Robert P. | - |
dc.contributor.author | Kim, J. K. | - |
dc.contributor.author | Bang, Y. J. | - |
dc.contributor.author | Lee, H. Y. | - |
dc.contributor.author | Friedland, David M. | - |
dc.contributor.author | Stoller, Ronald G. | - |
dc.contributor.author | Belani, Chandra P. | - |
dc.contributor.author | Ramanathan, Ramesh K. | - |
dc.date.accessioned | 2021-01-31T11:57:21Z | - |
dc.date.available | 2021-01-31T11:57:21Z | - |
dc.date.created | 2020-12-21 | - |
dc.date.issued | 2011-06 | - |
dc.identifier.citation | Journal of Liposome Research, Vol.21 No.2, pp.158-165 | - |
dc.identifier.issn | 0898-2104 | - |
dc.identifier.other | 119292 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173159 | - |
dc.description.abstract | Methods: aEuro,As part of a phase I study of S-CKD602 and phase I and II studies of NL-CKD602, the percent decreases in ANC and monocytes at their nadir were calculated. After S-CKD602, the amount of CKD-602 recovered in urine was measured. Results: aEuro,For S-CKD602 in patients < 60 years, the percent decrease in ANC and monocytes were 43 +/-+/- 31 and 58 +/-+/- 26%, respectively (P == 0.001). For S-CKD602 in patients >= a parts per thousand yen60, the percent decrease in ANC and monocytes were 41 +/-+/- 31 and 45 +/-+/- 36%, respectively (P == 0.50). For NL-CKD602 (n == 42), the percent decrease in ANC and monocytes were similar (P > 0.05). For S-CKD602, the relationship between the percent decrease in monocytes and CKD-602 recovered in urine was stronger in patients < 60 (R= a parts per thousand yen60 (R | - |
dc.language | 영어 | - |
dc.publisher | Marcel Dekker Inc. | - |
dc.title | Bidirectional pharmacodynamic interaction between pegylated liposomal CKD-602 (S-CKD602) and monocytes in patients with refractory solid tumors | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.3109/08982104.2010.496085 | - |
dc.citation.journaltitle | Journal of Liposome Research | - |
dc.identifier.wosid | 000290734600008 | - |
dc.identifier.scopusid | 2-s2.0-79956133712 | - |
dc.citation.endpage | 165 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 158 | - |
dc.citation.volume | 21 | - |
dc.identifier.sci | 000290734600008 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Bang, Y. J. | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PHASE-I | - |
dc.subject.keywordPlus | MACROPHAGE FUNCTION | - |
dc.subject.keywordPlus | OVARIAN-CARCINOMA | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | AGENTS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordAuthor | S-CKD602 | - |
dc.subject.keywordAuthor | STEALTH (R) liposomes | - |
dc.subject.keywordAuthor | monocytes | - |
dc.subject.keywordAuthor | pharmacokinetics | - |
dc.subject.keywordAuthor | clearance mechanisms | - |
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