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Outcomes of surgery aiming at curative resection in good responder to induction chemotherapy for gastric cancer with distant metastases

Cited 31 time in Web of Science Cited 31 time in Scopus
Authors
Han, Dong-Seok; Suh, Yun-Suhk; Kong, Seong-Ho; Lee, Hyuk-Joon; Im, Seock-Ah; Bang, Yung-Jue; Kim, Woo-Ho; Yang, Han-Kwang
Issue Date
2013-04
Citation
Journal of Surgical Oncology, Vol.107 No.5, pp.511-516
Keywords
gastric cancermetastasischemotherapygastrectomy
Abstract
Background The aim of this study is to analyze the outcome of surgery with curative intent in good responder to induction chemotherapy for gastric cancer with distant metastases (M1 gastric cancer). Materials and Methods We reviewed M1 gastric cancer patients in whom radiologic evaluation suggests disappearance of metastatic lesion after chemotherapy and received operation from January 2000 to December 2009. Clinicopathologic variables and oncologic outcomes were evaluated. Results Of the 34 patients who underwent surgery with curative intent after chemotherapy, overall R0 resection rate was 76.5% (26/34). R0 resection rate was 88.0% (22/25) in initial one metastatic site and 44.4% (4/9) in two metastatic sites (P=0.017). Postoperative morbidity and mortality rate were 14.7% and 0%. Recurrence rate was 61.5% (16/26) after R0 resection. Median survival was 22.9 and 7.8 months according to R0 versus non-R0 resection (P=0.033). After R0 resection, 3-year overall survival was 51.7% in ypN0-2 stage group. Conclusion The present study provides evidence that in patients with M1 gastric cancer which confined to one site who respond well to induction chemotherapy, a higher rate of R0 resection and longer survival can be expected. A multicenter cohort study is needed to explore this concept further. J. Surg. Oncol. 2013;107:511516. (c) 2012 Wiley Periodicals, Inc.
ISSN
0022-4790
URI
https://hdl.handle.net/10371/173170
DOI
https://doi.org/10.1002/jso.23284
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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