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The endogenous ratio of Smad2 and Smad3 influences the cytostatic function of Smad3
DC Field | Value | Language |
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dc.contributor.author | Kim, Sang Gyun | - |
dc.contributor.author | Kim, Hyun-Ah | - |
dc.contributor.author | Jong, Hyun-Soon | - |
dc.contributor.author | Park, Jung-Hyun | - |
dc.contributor.author | Kim, Noe Kyeong | - |
dc.contributor.author | Hong, Seung Hwan | - |
dc.contributor.author | Kim, Tae-You | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.date.accessioned | 2021-01-31T11:59:17Z | - |
dc.date.available | 2021-01-31T11:59:17Z | - |
dc.date.created | 2020-12-17 | - |
dc.date.issued | 2005-10 | - |
dc.identifier.citation | Molecular Biology of the Cell, Vol.16 No.10, pp.4672-4683 | - |
dc.identifier.issn | 1059-1524 | - |
dc.identifier.other | 119262 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173186 | - |
dc.description.abstract | Although Smad2 and Smad3, critical transcriptional mediators of transforming growth factor-beta (TGF-beta) signaling, are supposed to play a role in the TGF-beta cytostatic program, it remains unclear whether TGF-beta delivers cytostatic signals through both Smads equally or through either differentially. Here, we report that TGF-beta cytostatic signals rely on a Smad3-, but not a Smad2-, dependent pathway and that the intensity of TGF-beta cytostatic signals can be modulated by changing the endogenous ratio of Smad3 to Smad2. Depleting endogenous Smad3 by RNA interference sufficiently interfered with TGF-beta cytostatic actions in various TGF-beta-sensitive cell lines, whereas raising the relative endogenous ratio of Smad3 to Smad2, by depleting Smad2, markedly enhanced TGF-beta cytostatic response. Consistently, Smad3 activation and its transcriptional activity upon TGF-beta stimulation were facilitated in Smad2-depleted cells relative to controls. Most significantly, a single event of increasing this ratio by Smad2 depletion was sufficient to restore TGF-beta cytostatic action in cells resistant to TGF-beta. These findings suggest a new important determinant of sensitivity to TGF-beta cytostatic signaling. | - |
dc.language | 영어 | - |
dc.publisher | American Society for Cell Biology | - |
dc.title | The endogenous ratio of Smad2 and Smad3 influences the cytostatic function of Smad3 | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.1091/mbc.E05-01-0054 | - |
dc.citation.journaltitle | Molecular Biology of the Cell | - |
dc.identifier.wosid | 000232257700018 | - |
dc.identifier.scopusid | 2-s2.0-26244439497 | - |
dc.citation.endpage | 4683 | - |
dc.citation.number | 10 | - |
dc.citation.startpage | 4672 | - |
dc.citation.volume | 16 | - |
dc.identifier.sci | 000232257700018 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Sang Gyun | - |
dc.contributor.affiliatedAuthor | Kim, Noe Kyeong | - |
dc.contributor.affiliatedAuthor | Hong, Seung Hwan | - |
dc.contributor.affiliatedAuthor | Kim, Tae-You | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | GROWTH-FACTOR-BETA | - |
dc.subject.keywordPlus | HUMAN GASTRIC-CANCER | - |
dc.subject.keywordPlus | CELL-CYCLE ARREST | - |
dc.subject.keywordPlus | TGF-BETA | - |
dc.subject.keywordPlus | C-MYC | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL REPRESSION | - |
dc.subject.keywordPlus | TARGETED DISRUPTION | - |
dc.subject.keywordPlus | DEPENDENT KINASE | - |
dc.subject.keywordPlus | BINDING-ELEMENT | - |
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