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Truncation of the TGF-β type II receptor gene results in insensitivity to TGF-β in human gastric cancer cells : Truncation of the TGF-beta type II receptor gene results in insensitivity to TGF-beta in human gastric cancer cells
DC Field | Value | Language |
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dc.contributor.author | Yang, Han-Kwang | - |
dc.contributor.author | Kang, Shin Hyeok | - |
dc.contributor.author | Kim, Yong-Seok | - |
dc.contributor.author | Won, Kyungshick | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.contributor.author | Kim, Seong-Jin | - |
dc.date.accessioned | 2021-01-31T11:59:53Z | - |
dc.date.available | 2021-01-31T11:59:53Z | - |
dc.date.created | 2020-12-23 | - |
dc.date.issued | 1999-04 | - |
dc.identifier.citation | Oncogene, Vol.18 No.13, pp.2213-2219 | - |
dc.identifier.issn | 0950-9232 | - |
dc.identifier.other | 119599 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173194 | - |
dc.description.abstract | The transforming growth factor-beta (TGF-beta receptor system has been implicated in the development of resistance to the growth-inhibitory effects of TGF-beta. It has been reported that resistance to TGF-beta correlates with inactivation of the TGF-beta type II receptor (RII). In the present report, we examine the genetic changes in the TGF-beta RII gene of human gastric cancer cell lines, SNU-5 and SNU-668, which we had previously reported to express truncated TGF-beta RII transcripts. By independent PCR and Southern hybridization analysis of genomic DNA, we found that the genomic sequence of TGF-beta RII is truncated after exon 2 in SNU-5 and after exon 3 in SNU-668. This was confirmed by sequencing the TGF-beta RII cDNA cloned from a SNU-5 cDNA library. Predicted TGF-beta RII protein of SNU-5 cells based on sequencing data contains only a part of extracellular domain of TGF-beta RII. We demonstrate that cotransfection of 3TP-Lux and wild type TGF-beta RII restores the TGF-beta responsiveness in SNU-5 cells, suggesting that genetic changes in the TGF-beta RII gene of SNU-5 cells are responsible for the loss of sensitivity to TGF-beta. This is the first report demonstrating that truncation of the TGF-beta RII gene is an alternative mechanism to inactivate the TGF-beta signal transduction pathways. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Truncation of the TGF-β type II receptor gene results in insensitivity to TGF-β in human gastric cancer cells | - |
dc.title.alternative | Truncation of the TGF-beta type II receptor gene results in insensitivity to TGF-beta in human gastric cancer cells | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.1038/sj.onc.1202535 | - |
dc.citation.journaltitle | Oncogene | - |
dc.identifier.wosid | 000079525100005 | - |
dc.identifier.scopusid | 2-s2.0-0033119429 | - |
dc.citation.endpage | 2219 | - |
dc.citation.number | 13 | - |
dc.citation.startpage | 2213 | - |
dc.citation.volume | 18 | - |
dc.identifier.sci | 000079525100005 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Yang, Han-Kwang | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MICROSATELLITE INSTABILITY | - |
dc.subject.keywordPlus | COLORECTAL CANCERS | - |
dc.subject.keywordPlus | GROWTH-INHIBITION | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | COLON | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordAuthor | transforming growth factor-beta | - |
dc.subject.keywordAuthor | cancer | - |
dc.subject.keywordAuthor | mutation | - |
dc.subject.keywordAuthor | carcinogenesis | - |
dc.subject.keywordAuthor | receptor | - |
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