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Transcriptional repression of the transforming growth factor-β type I receptor gene by DNA methylation results in the development of TGF-β resistance in human gastric cancer : Transcriptional repression of the transforming growth factor-beta type I receptor gene by DNA methylation results in the development of TGF-beta resistance in human gastric cancer
DC Field | Value | Language |
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dc.contributor.author | Kang, Shin Hyeok | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.contributor.author | Im, Young-Hyuck | - |
dc.contributor.author | Yang, Han-Kwang | - |
dc.contributor.author | Lee, David A | - |
dc.contributor.author | Lee, Hwa Young | - |
dc.contributor.author | Lee, Ho Soon | - |
dc.contributor.author | Kim, Noe Kyeong | - |
dc.contributor.author | Kim, Seong-Jin | - |
dc.date.accessioned | 2021-01-31T11:59:56Z | - |
dc.date.available | 2021-01-31T11:59:56Z | - |
dc.date.created | 2020-12-23 | - |
dc.date.issued | 1999-12 | - |
dc.identifier.citation | Oncogene, Vol.18 No.51, pp.7280-7286 | - |
dc.identifier.issn | 0950-9232 | - |
dc.identifier.other | 119595 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173195 | - |
dc.description.abstract | The transforming growth factor-beta (TGF-beta) signaling pathway subserves an essential tumor suppressor function in various cell types. A heteromeric complex composed of TGF-beta type I (RI) and type II (RII) receptors is required for TGF-beta signaling. We have identified a subset of human gastric cancer cell lines which are insensitive to TGF-beta and which express a low level of TGF-beta type I receptor mRNA relative to a gastric cancer cell line which is highly responsive to TGF-beta. Using these cells, we show that hypermethylation of a CpG island in the 5' region of the TGF-beta RI gene provides another potentially important mechanism of escape from negative growth control by TGF-beta, This hypermethylation was found in four of five human gastric cancer cell lines and five out of 40 (12.5%) primary tumors examined, In human gastric cancer cell lines, treatment with the demethylating agent, 5-aza-2'-deoxycytidine, resulted in increased expression of the TGF-beta RI gene, but not the RII gene, Transient transfection of an RI expression vector into the TGF-beta resistant SNU-601 cell line restores TGF-beta responsiveness. These findings suggest that one of the mechanisms of escape from autocrine or paracrine growth control by TGF-beta during carcinogenesis could involve aberrant methylation of CpG islands in the 5' region of the TGF-beta RI gene. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Transcriptional repression of the transforming growth factor-β type I receptor gene by DNA methylation results in the development of TGF-β resistance in human gastric cancer | - |
dc.title.alternative | Transcriptional repression of the transforming growth factor-beta type I receptor gene by DNA methylation results in the development of TGF-beta resistance in human gastric cancer | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.1038/sj.onc.1203146 | - |
dc.citation.journaltitle | Oncogene | - |
dc.identifier.wosid | 000084119400012 | - |
dc.identifier.scopusid | 2-s2.0-0000031048 | - |
dc.citation.endpage | 7286 | - |
dc.citation.number | 51 | - |
dc.citation.startpage | 7280 | - |
dc.citation.volume | 18 | - |
dc.identifier.sci | 000084119400012 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.contributor.affiliatedAuthor | Yang, Han-Kwang | - |
dc.contributor.affiliatedAuthor | Kim, Noe Kyeong | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR GENE | - |
dc.subject.keywordPlus | COLON-CARCINOMA CELLS | - |
dc.subject.keywordPlus | MICROSATELLITE INSTABILITY | - |
dc.subject.keywordPlus | CPG ISLAND | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | MISMATCH REPAIR | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MALIGNANCY | - |
dc.subject.keywordPlus | PROMOTER | - |
dc.subject.keywordAuthor | transforming growth factor-beta | - |
dc.subject.keywordAuthor | CpG methylation | - |
dc.subject.keywordAuthor | cancer | - |
dc.subject.keywordAuthor | receptor | - |
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