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ABCB1, FCGR2A, and FCGR3A Polymorphisms in Patients with HER2-Positive Metastatic Breast Cancer Who Were Treated with First-Line Taxane plus Trastuzumab Chemotherapy

Cited 12 time in Web of Science Cited 14 time in Scopus
Authors
Kim, Ji-Won; Kim, Jee Hyun; Im, Seock-Ah; Kim, Yu Jung; Han, Hye-Suk; Kim, Jin-Soo; Han, Sae-Won; Jeon, Yoon Kyung; Oh, Do-Youn; Han, Wonshik; Kim, Tae-You; Park, In Ae; Noh, Dong-Young; Bang, Yung-Jue
Issue Date
2012-08
Citation
Oncology, Vol.83 No.4, pp.218-227
Keywords
ABCB1FCGR2AFCGR3APolymorphismTaxaneTrastuzumab
Abstract
Objective: The aim of this study was to elucidate clinical implications of ABCB1, FCGR2A, and FCGR3A polymorphisms in patients with HER2-positive metastatic breast cancer (MBC) after taxane plus trastuzumab (TH) chemotherapy. Methods: Using genomic DNA samples extracted from mononuclear cells of consecutive patients with HER2-positive MBC who received first-line TH, we analyzed five polymorphisms (ABCB1 1236C>T, ABCB1 2677G>T/A, ABCB1 3435C>T, FCGR2A 131H/R, and FCGR3A 158V/F) and then correlated them with the response rate, progression-free survival (PFS), overall survival (OS), and adverse events of patients. Results: A total of 57 women were analyzed. The median age was 46 years (range 27-72). ABCB1 2677T carriers had a longer PFS (p = 0.037) along with a tendency toward a longer OS (p = 0.057). ABCB1 3435CC genotype carriers had a shorter PFS (p = 0.039) along with a tendency toward a shorter OS (p = 0.093). In combined analysis, PFS was significantly longer in ABCB1 1236CC and/or 2677TT carriers compared to the others (p = 0.006). FCGR2A 131H/R and FCGR3A 158V/F polymorphisms were not significantly associated with response rate, PFS, and OS. Conclusions: Our data support that ABCB1 polymorphisms may predict PFS after first-line TH chemotherapy in patients with HER2-positive MBC. In contrast, FCGR2A 131H/R and FCGR3A 158V/F polymorphisms could not predict treatment outcomes. Copyright (C) 2012 S. Karger AG, Basel
ISSN
0030-2414
URI
https://hdl.handle.net/10371/173222
DOI
https://doi.org/10.1159/000341359
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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