Browse

Sunitinib for Asian Patients with Advanced Renal Cell Carcinoma: A Comparable Efficacy with Different Toxicity Profiles

Cited 42 time in Web of Science Cited 48 time in Scopus
Authors
Kim, Hyo Song; Hong, Min Hee; Kim, Kiyeol; Shin, Sang-Joon; Ahn, Joong-Bae; Jeung, Hei Chul; Chung, Hyun Cheol; Koh, Youngil; Lee, Se-Hoon; Bang, Yung-Jue; Rha, Sun Young
Issue Date
2011-08
Citation
Oncology, Vol.80 No.5-6, pp.395-405
Keywords
Renal cell cancerSunitinibToxicity
Abstract
Objective: We aimed to describe the efficacy and safety of sunitinib in unselected Korean advanced renal cell carcinoma (RCC) patients. Patients and Methods: From November 2005 to August 2008, 132 histologically confirmed advanced RCC patients (100 in the global expanded access program) were enrolled. Response and toxicity were assessed regularly according to the protocol. Results: Within this population, 82.6% had clear cell RCC, and 28.8% were treatment naive. Patients received a median of 5 cycles of sunitinib (range 1-30), and the mean relative dose intensity was 82.0 +/- 14.20 (SD). The progression-free survival (PFS) and overall survival rates were 8.2 and 23.1 months, respectively. For the 130 evaluable patients, the objective response rate was 34.1% (n = 45); 44.7% (n = 59) exhibited stable disease. Reasons for discontinuation were disease progression (75.0%) and toxicity (7.6%). The most frequent adverse events were thrombocytopenia (75.0%), neutropenia (70.5%), and anemia (69.7%). Low body surface area (OR = 4.2, 95% CI 1.2-13.8, p = 0.02) and previously treated status (OR = 3.1, 95% CI 1.3-7.4, p = 0.01) were highly predictive of grade 3-4 toxicities. Based on these findings, a nomogram predicting the probability of 12-month PFS was constructed, giving a concordance index of 0.675. Conclusions: Despite the different toxicity profiles, maintaining adequate dose modifications and a careful follow-up enables comparable treatment outcomes for unselected Korean advanced RCC patients. Copyright (C) 2011 S. Karger AG, Basel
ISSN
0030-2414
URI
https://hdl.handle.net/10371/173223
DOI
https://doi.org/10.1159/000330361
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse