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Toll-like receptor 2 downregulation and cytokine dysregulation predict mortality in patients with Staphylococcus aureus bacteremia
DC Field | Value | Language |
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dc.contributor.author | Kim, Nak-Hyun | - |
dc.contributor.author | Sung, Ji Yeon | - |
dc.contributor.author | Choi, Yoon Jung | - |
dc.contributor.author | Choi, Su-Jin | - |
dc.contributor.author | Ahn, Soyeon | - |
dc.contributor.author | Ji, Eunjeong | - |
dc.contributor.author | Kim, Moonsuk | - |
dc.contributor.author | Kim, Chung Jong | - |
dc.contributor.author | Song, Kyoung-Ho | - |
dc.contributor.author | Choe, Pyoeng Gyun | - |
dc.contributor.author | Park, Wan Beom | - |
dc.contributor.author | Kim, Eu Suk | - |
dc.contributor.author | Park, Kyoung Un | - |
dc.contributor.author | Kim, Nam-Joong | - |
dc.contributor.author | Oh, Myoung-don | - |
dc.contributor.author | Kim, Hong Bin | - |
dc.date.accessioned | 2021-02-19T01:40:24Z | - |
dc.date.available | 2021-02-19T10:41:36Z | - |
dc.date.issued | 2020-11-30 | - |
dc.identifier.citation | BMC Infectious Diseases. 2020 Nov 30;20(1):901 | ko_KR |
dc.identifier.issn | 1471-2334 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173354 | - |
dc.description.abstract | Background
Staphylococcus aureus bacteremia (SAB) presents heterogeneously, owing to the differences in underlying host conditions and immune responses. Although Toll-like receptor 2 (TLR2) is important in recognizing S. aureus, its function during S. aureus infection remains controversial. We aimed to examine the association of TLR2 expression and associated cytokine responses with clinical SAB outcomes. Methods Patients from a prospective SAB cohort at two tertiary-care medical centers were enrolled. Blood was sampled at several timepoints (≤5 d, 6–9 d, 10–13 d, 14–19 d, and ≥ 20 d) after SAB onset. TLR2 mRNA levels were determined via real-time PCR and serum tumor necrosis factor [TNF]-α, interleukin [IL]-6, and IL-10 levels were analyzed with multiplex-high-sensitivity electrochemiluminescent ELISA. Results TLR2 levels varied among 59 SAB patients. On days 2–5, TLR2 levels were significantly higher in SAB survivors than in healthy controls (p = 0.040) and slightly but not significantly higher than non-survivors (p = 0.120), and SAB patients dying within 7 d had lower TLR2 levels than survivors (P = 0.077) although statistically insignificant. IL-6 and IL-10 levels were significantly higher in non-survivors than in survivors on days 2–5 post-bacteremia (P = 0.010 and P = 0.021, respectively), and those dying within 7 d of SAB (n = 3) displayed significantly higher IL-10/TNF-α ratios than the survivors did (P = 0.007). Conclusion TLR2 downregulation and IL-6 and IL-10 concentrations suggestive of immune dysregulation during early bacteremia may be associated with mortality from SAB. TLR2 expression levels and associated cytokine reactions during early-phase SAB may be potential prognostic factors in SAB, although larger studies are warranted. | ko_KR |
dc.description.sponsorship | This study was supported by a research grant (13–2014-002) from Seoul National University Bundang Hospital (Seongnam, South Korea). The funder had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Staphylococcus aureus | - |
dc.subject | Bacteremia | - |
dc.subject | Toll-like receptor 2 (TLR2) | - |
dc.subject | Cytokines | - |
dc.title | Toll-like receptor 2 downregulation and cytokine dysregulation predict mortality in patients with Staphylococcus aureus bacteremia | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김낙현 | - |
dc.contributor.AlternativeAuthor | 성지연 | - |
dc.contributor.AlternativeAuthor | 최윤정 | - |
dc.contributor.AlternativeAuthor | 최수진 | - |
dc.contributor.AlternativeAuthor | 안소연 | - |
dc.contributor.AlternativeAuthor | 지은정 | - |
dc.contributor.AlternativeAuthor | 김문숙 | - |
dc.contributor.AlternativeAuthor | 김정종 | - |
dc.contributor.AlternativeAuthor | 송경호 | - |
dc.contributor.AlternativeAuthor | 최평균 | - |
dc.contributor.AlternativeAuthor | 박완범 | - |
dc.contributor.AlternativeAuthor | 김의숙 | - |
dc.contributor.AlternativeAuthor | 박경운 | - |
dc.contributor.AlternativeAuthor | 김남중 | - |
dc.contributor.AlternativeAuthor | 오명돈 | - |
dc.contributor.AlternativeAuthor | 김홍빈 | - |
dc.identifier.doi | 10.1186/s12879-020-05641-z | - |
dc.citation.journaltitle | BMC Infectious Diseases | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2021-01-27T09:17:54Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 901 | ko_KR |
dc.citation.volume | 21 | ko_KR |
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