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Actual long-term survival after resection of stage III soft tissue sarcoma

DC Field Value Language
dc.contributor.authorLee, Do Weon-
dc.contributor.authorKim, Han-Soo-
dc.contributor.authorHan, Ilkyu-
dc.date.accessioned2021-02-23T05:51:50Z-
dc.date.available2021-02-23T14:53:14Z-
dc.date.issued2021-01-05-
dc.identifier.citationBMC Cancer. 2021 Jan 05;21(1):21ko_KR
dc.identifier.issn1471-2407-
dc.identifier.urihttps://hdl.handle.net/10371/173376-
dc.description.abstractBackground
Actuarial survival based on the Kaplan–Meier method can overestimate actual long-term survival, especially among those with factors of poor prognosis. Patients with American Joint Committee on Cancer stage III soft tissue sarcoma (STS) represent a subset with a high risk of STS-specific mortality. Therefore, we aimed to characterize the clinicopathological characteristics associated with actual long-term survival in patients with stage III STS.

Methods
We retrospectively reviewed 116 patients who underwent surgical resection for stage III STS with curative intent between March 2000 and December 2013. Long-term survivors (n = 61), defined as those who survived beyond 5 years, were compared with short-term survivors (n = 36), who died of STS within 5 years.

Results
Multivariate logistic regression analyses showed that a tumor size < 10 cm [odds ratio (OR) 3.95, p = 0.047], histological grade of 2 (OR 8.12, p = 0.004), and American Society of Anesthesiologists (ASA) score of 1 (OR 11.25, p = 0.001) were independently associated with actual 5-year survival. However, 66% of the long-term survivors exhibited factors of poor prognosis: 36% had a tumor size > 10 cm and 48% had a histological grade of 3. Leiomyosarcoma (3 of 10) was negatively associated with actual long-term survival.

Conclusions
Actual 5-year survival after resection of stage III STS was associated with tumor size, histological grade, and ASA score. However, majority of the actual 5-year survivors exhibit factors of poor prognosis, suggesting that aggressive treatment should be offered for a chance of long-term survival in these patients.
ko_KR
dc.language.isoenko_KR
dc.publisherBMCko_KR
dc.subjectSarcoma-
dc.subjectSoft tissue sarcoma-
dc.subjectSurvival-
dc.titleActual long-term survival after resection of stage III soft tissue sarcomako_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이도원-
dc.contributor.AlternativeAuthor김한수-
dc.contributor.AlternativeAuthor한일규-
dc.identifier.doi10.1186/s12885-020-07730-3-
dc.citation.journaltitleBMC Cancerko_KR
dc.language.rfc3066en-
dc.rights.holderThe Author(s)-
dc.date.updated2021-01-27T09:42:46Z-
dc.citation.number1ko_KR
dc.citation.startpage21ko_KR
dc.citation.volume21ko_KR
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Orthopedic Surgery (정형외과학전공)Journal Papers (저널논문_정형외과학전공)
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