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Effectiveness of mechanical thrombectomy in cancer-related stroke and associated factors with unfavorable outcome
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Eung-Joon | - |
dc.contributor.author | Bae, Jeonghoon | - |
dc.contributor.author | Jeong, Hae-Bong | - |
dc.contributor.author | Lee, Eun Ji | - |
dc.contributor.author | Jeong, Han-Yeong | - |
dc.contributor.author | Yoon, Byung-Woo | - |
dc.date.accessioned | 2021-04-28T07:17:38Z | - |
dc.date.available | 2021-04-28T16:19:05Z | - |
dc.date.issued | 2021-02-06 | - |
dc.identifier.citation | BMC Neurology. 2021 Feb 06;21(1):57 | ko_KR |
dc.identifier.issn | 1471-2377 | - |
dc.identifier.uri | https://hdl.handle.net/10371/174155 | - |
dc.description.abstract | Background
The effectiveness of mechanical thrombectomy (MT) in cancer-related stroke (CRS) is largely unknown. This study aims to investigate the clinical and radiological outcomes of MT in CRS patients. We also explored the factors that independently affect functional outcomes of patients with CRS after MT. Methods We retrospectively reviewed 341 patients who underwent MT after acute ischemic stroke onset between May 2014 and May 2020. We classified the patients into CRS (n = 34) and control (n = 307) groups and compared their clinical details. Among CRS patients, we analyzed the groups with and without good outcomes (3-months modified Rankin scale [mRS] score 0, 1, 2). Multivariate analysis was performed to investigate the independent predictors of unfavorable outcomes in patients with CRS after MT. Results A total of 341 acute ischemic stroke patients received MT, of whom 34 (9.9%) had CRS. Although the baseline National institute of health stroke scale (NIHSS) score and the rate of successful recanalization was not significantly different between CRS patients and control group, CRS patients showed more any cerebral hemorrhage after MT (41.2% vs. controls 23.8%, p = 0.037) and unfavorable functional outcome at 3 months (CRS patients median 3-month mRS score 4, interquartile range [IQR] 2 to 5.25 vs. controls median 3-month mRS score 3, IQR 1 to 4, [p = 0.026]). In the patients with CRS, elevated serum D-dimer level and higher baseline NIHSS score were independently associated with unfavorable functional outcome at 3 months (adjusted odds ratio [aOR]: 1.524, 95% confidence interval [CI]: 1.043–2.226; aOR: 1.264, 95% CI: 1.010–1.582, respectively). Conclusions MT is an appropriate therapeutic treatment for revascularization in CRS patients. However, elevated serum D-dimer levels and higher baseline NIHSS scores were independent predictors of unfavorable outcome. Further research is warranted to evaluate the significance of these predictors. | ko_KR |
dc.description.sponsorship | This research was supported by a fund (#2020ER620200) by the Korea
Centers for Disease Control & Prevention and Clinical Research Society for Stroke, Republic of Korea. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Stroke | - |
dc.subject | Endovascular treatment | - |
dc.subject | Neoplasm | - |
dc.subject | Neoplasm metastasis | - |
dc.subject | Outcome | - |
dc.title | Effectiveness of mechanical thrombectomy in cancer-related stroke and associated factors with unfavorable outcome | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이응준 | - |
dc.contributor.AlternativeAuthor | 배정훈 | - |
dc.contributor.AlternativeAuthor | 정해봉 | - |
dc.contributor.AlternativeAuthor | 이은지 | - |
dc.contributor.AlternativeAuthor | 정한영 | - |
dc.contributor.AlternativeAuthor | 윤병우 | - |
dc.identifier.doi | 10.1186/s12883-021-02086-y | - |
dc.citation.journaltitle | BMC Neurology | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2021-02-15T10:30:10Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.volume | 21 | ko_KR |
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