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Predictors of a placebo response in patients with hand osteoarthritis: post-hoc analysis of two randomized controlled trials
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Jin Kyun | - |
dc.contributor.author | Ahn, Se Han | - |
dc.contributor.author | Shin, Kichul | - |
dc.contributor.author | Lee, Yun Jong | - |
dc.contributor.author | Song, Yeong Wook | - |
dc.contributor.author | Lee, Eun Bong. | - |
dc.date.accessioned | 2021-05-14T06:35:05Z | - |
dc.date.available | 2021-05-14T15:36:29Z | - |
dc.date.issued | 2021-03-04 | - |
dc.identifier.citation | BMC Musculoskeletal Disorders. 2021 Mar 04;22(1):244 | ko_KR |
dc.identifier.issn | 1471-2474 | - |
dc.identifier.uri | https://hdl.handle.net/10371/174369 | - |
dc.description.abstract | Background
Placebo can have a significant therapeutic effect in patients with hand osteoarthritis (OA). This aim of the study is to identify factors associated with a clinically meaningful placebo response in patients with hand OA. Methods This post-hoc analysis of two double-blind, placebo-controlled, randomized trials (RCTs) investigating the efficacy of GCSB-5 or diacerein as treatments for hand OA analyzed the efficacy of a placebo. Clinical and laboratory factors associated with a clinically meaningful response, defined as an improvement in the Australian/Canadian Osteoarthritis Hand Index (AUSCAN) pain score > 10 at 4 weeks relative to baseline, were identified. Results The mean improvement in the AUSCAN pain score was − 6.0 ± 20.3, with marked variation between 143 hand OA patients (range: − 76.4 to 33.2). A clinically meaningful improvement was observed in 54 (37.8%) patients. Placebo responders had worse AUSCAN pain scores (55.7 ± 19.7 vs. 43.6 ± 21.6, p= 0.001) and a worse AUSCAN stiffness (68.2 ± 20.5 vs. 57.5 ± 24.5, p= 0.008) at baseline than non-responders. Improvements in pain correlated with the baseline pain level (Pearson r= − 427, p< 0.001). Structural joint changes such as tender, swollen, enlarged, or deformed joint counts did not differ between placebo responders and non-responders. In a multivariable analysis, only baseline AUSCAN pain was associated with a clinically meaningful placebo response (OR: 1.054, 95% CI [1.019–1.089], p= 0.002). Conclusions High levels of pain at baseline are predictive of a clinically meaningful placebo response in patients with hand OA. Further studies are needed to optimize and utilize the benefit of placebo responses in patients with hand OA. | ko_KR |
dc.description.sponsorship | This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI15C1136, HC17C0069). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Osteoarthritis | - |
dc.subject | Hand | - |
dc.subject | Placebo | - |
dc.title | Predictors of a placebo response in patients with hand osteoarthritis: post-hoc analysis of two randomized controlled trials | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 박진균 | - |
dc.contributor.AlternativeAuthor | 안세한 | - |
dc.contributor.AlternativeAuthor | 신기철 | - |
dc.contributor.AlternativeAuthor | 이윤종 | - |
dc.contributor.AlternativeAuthor | 송영욱 | - |
dc.contributor.AlternativeAuthor | 이은봉 | - |
dc.identifier.doi | doi.org/10.1186/s12891-021-04089-9 | - |
dc.citation.journaltitle | BMC Musculoskeletal Disorders | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2021-03-07T05:45:18Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 244 | ko_KR |
dc.citation.volume | 22 | ko_KR |
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