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Microvascularized tumor organoids-on-chips: advancing preclinical drug screening with pathophysiological relevance
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, Jungeun | - |
dc.contributor.author | Ching, Hanna | - |
dc.contributor.author | Yoon, Jeong-Kee | - |
dc.contributor.author | Jeon, Noo Li | - |
dc.contributor.author | Kim, YongTae | - |
dc.date.accessioned | 2021-07-09T06:12:43Z | - |
dc.date.available | 2021-07-09T15:15:45Z | - |
dc.date.issued | 2021-04-13 | - |
dc.identifier.citation | Nano Convergence. 2021 Apr 13;8(1):12 | ko_KR |
dc.identifier.issn | 2196-5404 | - |
dc.identifier.uri | https://hdl.handle.net/10371/174675 | - |
dc.description.abstract | Recent developments of organoids engineering and organ-on-a-chip microfluidic technologies have enabled the recapitulation of the major functions and architectures of microscale human tissue, including tumor pathophysiology. Nevertheless, there remain challenges in recapitulating the complexity and heterogeneity of tumor microenvironment. The integration of these engineering technologies suggests a potential strategy to overcome the limitations in reconstituting the perfusable microvascular system of large-scale tumors conserving their key functional features. Here, we review the recent progress of in vitro tumor-on-a-chip microfluidic technologies, focusing on the reconstruction of microvascularized organoid models to suggest a better platform for personalized cancer medicine. | ko_KR |
dc.description.sponsorship | This work was supported by the National Institutes of Health Directors New Innovator Award 1DP2HL142050 (Y.K.) and the National Science Foundation under CAREER CMMI 1653006 (Y.K.). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | Springer Open | ko_KR |
dc.subject | Microfuidics | - |
dc.subject | Tumor organoids | - |
dc.subject | Microvasculature | - |
dc.subject | Organ-on-a-chip | - |
dc.title | Microvascularized tumor organoids-on-chips: advancing preclinical drug screening with pathophysiological relevance | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 임정은 | - |
dc.contributor.AlternativeAuthor | 윤정기 | - |
dc.contributor.AlternativeAuthor | 전누리 | - |
dc.contributor.AlternativeAuthor | 김용태 | - |
dc.identifier.doi | 10.1186/s40580-021-00261-y | - |
dc.citation.journaltitle | Nano Convergence | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2021-04-18T03:16:28Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 12 | ko_KR |
dc.citation.volume | 8 | ko_KR |
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