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Drosophila Graf regulates mushroom body β-axon extension and olfactory long-term memory
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sungdae | - |
dc.contributor.author | Kim, Joohyung | - |
dc.contributor.author | Park, Sunyoung | - |
dc.contributor.author | Park, Joong-Jean | - |
dc.contributor.author | Lee, Seungbok | - |
dc.date.accessioned | 2021-07-12T04:28:26Z | - |
dc.date.available | 2021-07-12T13:30:16Z | - |
dc.date.issued | 2021-04-23 | - |
dc.identifier.citation | Molecular Brain. 2021 Apr 23;14(1):73 | ko_KR |
dc.identifier.issn | 1756-6606 | - |
dc.identifier.uri | https://hdl.handle.net/10371/174682 | - |
dc.description.abstract | Abstract
Loss-of-function mutations in the human oligophrenin-1 (OPHN1) gene cause intellectual disability, a prevailing neurodevelopmental condition. However, the role OPHN1 plays during neuronal development is not well understood. We investigated the role of the Drosophila OPHN1 ortholog Graf in the development of the mushroom body (MB), a key brain structure for learning and memory in insects. We show that loss of Graf causes abnormal crossing of the MB β lobe over the brain midline during metamorphosis. This defect in Graf mutants is rescued by MB-specific expression of Graf and OPHN1. Furthermore, MB α/β neuron-specific RNA interference experiments and mosaic analyses indicate that Graf acts via a cell-autonomous mechanism. Consistent with the negative regulation of epidermal growth factor receptor (EGFR)-mitogen-activated protein kinase (MAPK) signaling by Graf, activation of this pathway is required for the β-lobe midline-crossing phenotype of Graf mutants. Finally, Graf mutants have impaired olfactory long-term memory. Our findings reveal a role for Graf in MB axon development and suggest potential neurodevelopmental functions of human OPHN1. | ko_KR |
dc.description.sponsorship | This work was supported by grants from the National Research Foundation of Korea (2017M3C7A1025368 and 2019R1A2C2089437). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Drosophila | - |
dc.subject | Intellectual disability | - |
dc.subject | Graf/oligophrenin-1 | - |
dc.subject | EGFR signaling | - |
dc.subject | Mushroom body development | - |
dc.title | Drosophila Graf regulates mushroom body β-axon extension and olfactory long-term memory | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김성대 | - |
dc.contributor.AlternativeAuthor | 김주형 | - |
dc.contributor.AlternativeAuthor | 박선영 | - |
dc.contributor.AlternativeAuthor | 박중진 | - |
dc.contributor.AlternativeAuthor | 이승복 | - |
dc.identifier.doi | 10.1186/s13041-021-00782-x | - |
dc.citation.journaltitle | Molecular Brain | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2021-04-25T03:21:08Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 73 | ko_KR |
dc.citation.volume | 14 | ko_KR |
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