Publications
Detailed Information
Roles of lysine-specific demethylase 1 (LSD1) in homeostasis and diseases
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Dongha | - |
dc.contributor.author | Kim, Keun Il. | - |
dc.contributor.author | Baek, Sung Hee | - |
dc.date.accessioned | 2021-08-12T05:54:30Z | - |
dc.date.available | 2021-08-12T15:36:48Z | - |
dc.date.issued | 2021-06-04 | - |
dc.identifier.citation | Journal of Biomedical Science. 2021 Jun 04;28(1):41 | ko_KR |
dc.identifier.issn | 1474-760X | - |
dc.identifier.uri | https://hdl.handle.net/10371/174786 | - |
dc.description.abstract | Abstract
Lysine-specific demethylase 1 (LSD1) targets mono- or di-methylated histone H3K4 and H3K9 as well as non-histone substrates and functions in the regulation of gene expression as a transcriptional repressor or activator. This enzyme plays a pivotal role in various physiological processes, including development, differentiation, inflammation, thermogenesis, neuronal and cerebral physiology, and the maintenance of stemness in stem cells. LSD1 also participates in pathological processes, including cancer as the most representative disease. It promotes oncogenesis by facilitating the survival of cancer cells and by generating a pro-cancer microenvironment. In this review, we discuss the role of LSD1 in several aspects of cancer, such as hypoxia, epithelial-to-mesenchymal transition, stemness versus differentiation of cancer stem cells, as well as anti-tumor immunity. Additionally, the current understanding of the involvement of LSD1 in various other pathological processes is discussed. | ko_KR |
dc.description.sponsorship | This work was supported by Creative Research Initiatives Programs (Research Science Research Center Program (Cellular Heterogeneity Research Center, NRF-2016 R1A5A1011974) to K.I.K.; Young Researcher Program (NRF2019R1C1C1004022) to D.K. from the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Cancer | - |
dc.subject | Hypoxia | - |
dc.subject | Infammation | - |
dc.subject | Immunity | - |
dc.subject | Neurodegenerative diseases | - |
dc.title | Roles of lysine-specific demethylase 1 (LSD1) in homeostasis and diseases | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김동하 | - |
dc.contributor.AlternativeAuthor | 김근일 | - |
dc.contributor.AlternativeAuthor | 백성희 | - |
dc.identifier.doi | 10.1186/s12929-021-00737-3 | - |
dc.citation.journaltitle | Journal of Biomedical Science | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2021-06-06T03:14:45Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 41 | ko_KR |
dc.citation.volume | 28 | ko_KR |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.